Leaving no stone unturned: the search for stroke associated with atrial fibrillation

© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.The diagnosis of paroxysmal atrial fibrillation (AF) continues to be a main priority in stroke patients. After the clinical trials that evaluated anticoagulation versus antiplatelet treatment in patients with embolic stroke of undetermined source (ESUS) showed that there is no benefit of anticoagulation in the absence of a diagnosis of AF, diagnosing paroxysmal AF continues to be an essential part of the etiological investigation of stroke patients. However, finding paroxysmal AF may be challenging.