Background: Neurodegenerative diseases known as α-synucleinopathies, most notably dementias and Parkinson’s Disease (PD), are characterized by neuronal aggregation and accumulation of α-synuclein (α-syn) in a manner that is deleterious to neurological health. Endogenous α-syn is involved in many cellular processes including synaptic vesicle homeostasis, the modulation of dopamine biosynthesis, and chaperone vesical exocytosis and neurotransmission. However, excessive α-syn accumulation in an aggregated form can be detrimental to cellular health. A known modulator of α-syn aggregation is docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid highly enriched in the brain. While DHA is well established as a neuroprotective m...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
UnlabelledAlzheimer's disease (AD) is characterized by the progressive accumulation of amyloid β (Aβ...
Objective: Whereas the contribution of α-synuclein to neurodegeneration in Parkinson disease is well...
Background: Neurodegenerative diseases known as a-synucleinopathies, most notably dementias and Park...
The omega-3 fatty acid, docosahexaenoic acid (DHA), is highly enriched in the central nervous system...
α-Synuclein (aS) is a protein abundant in presynaptic nerve terminals in Parkinson disease (PD) and ...
Summary: The lack of disease-modifying treatments for neurodegenerative disease stems in part from o...
The interaction of brain lipids with α-synuclein may play an important role in the pathogenesis of P...
α-Synuclein (α-syn) is a 140-amino acid protein, the physiological function of which has...
AbstractAccumulation of misfolded proteins as insoluble aggregates occurs in several neurodegenerati...
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by striatoni...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions that ar...
α-Synuclein (α-syn) is a major constituent of neuronal inclusions known as Lewy bodies (LBs), which ...
AbstractFree radicals, including dopamine (DA)-oxidized metabolites, have long been implicated in pa...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
UnlabelledAlzheimer's disease (AD) is characterized by the progressive accumulation of amyloid β (Aβ...
Objective: Whereas the contribution of α-synuclein to neurodegeneration in Parkinson disease is well...
Background: Neurodegenerative diseases known as a-synucleinopathies, most notably dementias and Park...
The omega-3 fatty acid, docosahexaenoic acid (DHA), is highly enriched in the central nervous system...
α-Synuclein (aS) is a protein abundant in presynaptic nerve terminals in Parkinson disease (PD) and ...
Summary: The lack of disease-modifying treatments for neurodegenerative disease stems in part from o...
The interaction of brain lipids with α-synuclein may play an important role in the pathogenesis of P...
α-Synuclein (α-syn) is a 140-amino acid protein, the physiological function of which has...
AbstractAccumulation of misfolded proteins as insoluble aggregates occurs in several neurodegenerati...
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by striatoni...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions that ar...
α-Synuclein (α-syn) is a major constituent of neuronal inclusions known as Lewy bodies (LBs), which ...
AbstractFree radicals, including dopamine (DA)-oxidized metabolites, have long been implicated in pa...
Neurodegenerative diseases share the unifying features of insoluble protein aggregates and irreversi...
UnlabelledAlzheimer's disease (AD) is characterized by the progressive accumulation of amyloid β (Aβ...
Objective: Whereas the contribution of α-synuclein to neurodegeneration in Parkinson disease is well...