Telomere length and mitochondrial DNA copy number in bipolar disorder: a sibling study.
- Spano, L.
- Etain, B.
- Laplanche, J-L
- Leboyer, M.
- Gard, S.
- Bellivier, F.
- Marie-Claire, Cynthia
- Laplanche, J-L.
DOIAbstract
International audienceAn accelerated cellular aging has been observed in bipolar disorder (BD) using biomarkers such as telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Several risk factors might drive premature aging in individuals with BD, including a familial predisposition. This study compared TL and mtDNAcn between individuals with BD and their (un)-affected siblings, and explored factors that may explain proband-sibling differences
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