We study the instanton contributions of N=2 supersymmetric gauge theory and propose that the instanton moduli space is mapped to the moduli space of punctured spheres. Due to the recursive structure of the boundary in the Deligne-Knudsen-Mumford stable compactification, this leads to a new recursion relation for the instanton coefficients, which is bilinear. Instanton contributions are expressed as integrals on M_{0,n} in the framework of the Liouville F-models. This also suggests considering instanton contributions as a kind of Hurwitz numbers and also provides a prediction on the asymptotic form of the Gromov-Witten invariants. We also interpret this map in terms of the geometric engineering approach to the gauge theory, namely the topol...