Novel imaging and bioprinting approaches for auricular cartilage regeneration

The focus of this thesis was to advance the methods and knowledge of the field of biofabrication by applying its techniques to improve current ear reconstruction for the congenital condition microtia. Three key areas were explored: advanced large format histology methods for deeper characterisation of the native cartilage tissue; a low-cost method of 3D imaging using ultrasound to capture patient anatomy; and novel multi-material 3D printed scaffold designs for regenerating cartilage. The novel methods developed in this work will contribute towards the future of advanced medical manufacturing for microtia as well as other patient specific implants