Synthesis of New Polyunsaturated Fatty Acid Ester of Hydroxyl Fatty Acid (FAHFA): Stearoyl Acid Ester of Leukotriene B4 (LTB4)

Fatty acid ester of hydroxyl fatty acid (FAHFA) is a molecule family of lipid ester. In recent years,some of them have showed function on anti-inflammation, anti-diabetes. Among them, a unique kind of polyunsaturated FAHFA-13-HODE was discovered and found it reversed the original harmful effect as a mediator in metabolism from its hydroxyl fatty acid part. Inspired by this phenomenon, Leukotriene B4 as a mediator in cell leading to many harmful effects was chosen as the hydroxyl fatty acid part of new FAHFAs and these FAHFAs were expected to have beneficial biological function. In this research, in order to test this hypothesis, polyunsaturated FAHFAs--------5-stearoyl acid ester of LTB4 and 12-stearoyl acid ester of LTB4 were synthesized, which consisted of hydroxyl fatty acid (HFA)-racemic leukotriene B4 analogies and fatty acid (FA)-stearoyl aci