Nearly 20,000 people died from cocaine overdoses in 2020 (NIDA, 2020). Similarly, overdose deaths involving opioids reached 70,000 following the pandemic (NIDA, 2021). Despite the impact that these disorders have on society, there are no FDA approved drug treatments for CUD and only three for OUD. Therefore, more effective treatment options are needed.One possible target for new pharmacotherapies is the GABA-A system. Methylglyoxal, an endogenous product, is a GABA-A agonist (Distler et al. 2012). The enzyme GLO1, metabolizes MG; thus, GLO1 inhibitors increase levels of MG. Studies have shown the co-administration of a GABA-A agonist, Midazolam, with cocaine potentiates the locomotor activation of cocaine (Morris, 2008). Similarly, co-admin...
Repeated cocaine administration induces behavioral sensitization in about 50 % of treated animals. N...
Epigenetic-based therapeutics are promising treatment options for Substance Use Disorder (SUD) due t...
Drug dependence is a major health issue worldwide, which is characterised by its persistence and hig...
Nearly 20,000 people died from cocaine overdoses in 2020 (NIDA, 2020). Similarly, overdose deaths in...
BACKGROUND:Glyoxalase 1 (GLO1) is an enzyme that metabolizes methylglyoxal (MG), which is a competit...
Cocaine use disorder continues be a significant public health concern with no available FDA-approved...
Previous studies have identified an association between the gene glyoxalase 1 (Glo1) and anxiety-lik...
COR659 is a recently synthesized positive allosteric modulator (PAM) of the GABAB receptor. Similarl...
The GABAergic system is the primary inhibitory regulator of the mesolimbic dopamine system, mediatin...
Current pharmacotherapies for depression exhibit slow onset, side effects and limited efficacy. Ther...
Cocaine use disorder continues be a significant public health concern with no available FDA-approved...
Exposure to cocaine induces selective behavioral and molecular adaptations. In rodents, acute cocain...
International audienceBehavioral sensitization to psychostimulants is associated with changes in dop...
Background and purpose: High rates of cigarette smoking occur in cocaine dependent individuals, refl...
Stimulant use disorder is a psychiatric illness that is characterized by repeated use of stimulant d...
Repeated cocaine administration induces behavioral sensitization in about 50 % of treated animals. N...
Epigenetic-based therapeutics are promising treatment options for Substance Use Disorder (SUD) due t...
Drug dependence is a major health issue worldwide, which is characterised by its persistence and hig...
Nearly 20,000 people died from cocaine overdoses in 2020 (NIDA, 2020). Similarly, overdose deaths in...
BACKGROUND:Glyoxalase 1 (GLO1) is an enzyme that metabolizes methylglyoxal (MG), which is a competit...
Cocaine use disorder continues be a significant public health concern with no available FDA-approved...
Previous studies have identified an association between the gene glyoxalase 1 (Glo1) and anxiety-lik...
COR659 is a recently synthesized positive allosteric modulator (PAM) of the GABAB receptor. Similarl...
The GABAergic system is the primary inhibitory regulator of the mesolimbic dopamine system, mediatin...
Current pharmacotherapies for depression exhibit slow onset, side effects and limited efficacy. Ther...
Cocaine use disorder continues be a significant public health concern with no available FDA-approved...
Exposure to cocaine induces selective behavioral and molecular adaptations. In rodents, acute cocain...
International audienceBehavioral sensitization to psychostimulants is associated with changes in dop...
Background and purpose: High rates of cigarette smoking occur in cocaine dependent individuals, refl...
Stimulant use disorder is a psychiatric illness that is characterized by repeated use of stimulant d...
Repeated cocaine administration induces behavioral sensitization in about 50 % of treated animals. N...
Epigenetic-based therapeutics are promising treatment options for Substance Use Disorder (SUD) due t...
Drug dependence is a major health issue worldwide, which is characterised by its persistence and hig...