We study naturally occurring genera (i.e. cobordism invariants) from the deformation theory in- spired by supersymmetric quantum mechanics. First, we construct a canonical deformation quantization for symplectic supermanifolds. This gives a novel proof of the super-analogue of Fedosov quantization. Our proof uses the formalism of Gelfand-Kazhdan descent, whose foundations we establish in the super-symplectic setting. In the second part of this thesis, we prove a super-version of Nest-Tsygan’s algebraic index theorem, generalizing work of Engeli. This work is inspired by the appearance of the same genera in three related stories: index theory, trace methods in deformation theory, and partition functions in quantum field theory. Using the ...