SARS-CoV-2 evolution threatens vaccine- and natural infection–derived immunity and the efficacy of therapeutic antibodies. To improve public health preparedness, we sought to predict which existing amino acid mutations in SARS-CoV-2 might contribute to future variants of concern. We tested the predictive value of features comprising epidemiology, evolution, immunology, and neural network–based protein sequence modeling and identified primary biological drivers of SARS-CoV-2 intrapandemic evolution. We found evidence that ACE2-mediated transmissibility and resistance to population-level host immunity has waxed and waned as a primary driver of SARS-CoV-2 evolution over time. We retroactively identified with high accuracy (area under the recei...
Our understanding of the still unfolding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...
SARS-CoV-2 variants with enhanced transmissibility represent a serious threat to global health. Here...
The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines...
SARS-CoV-2 evolution threatens vaccine- and natural infection–derived immunity and the efficacy of t...
Accurate and reliable forecasting of emerging dominant severe acute respiratory syndrome coronavirus...
International audienceSignificance During the COVID pandemic, new severe acute respiratory syndrome ...
BackgroundA mechanistic understanding of the spread of SARS-CoV-2 and diligent tracking of ongoing m...
BackgroundA mechanistic understanding of the spread of SARS-CoV-2 and diligent tracking of ongoing m...
BackgroundA mechanistic understanding of the spread of SARS-CoV-2 and diligent tracking of ongoing m...
The continual evolution of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the ...
The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines...
The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines...
Predicting SARS-CoV-2 mutations is difficult, but predicting recurrent mutations driven by the host,...
The rise of SARS-CoV-2 variants and the history of outbreaks caused by zoonotic coronaviruses point ...
Scientists have made great efforts to understand the evolution of SARS-CoV-2 (Severe Acute Respirato...
Our understanding of the still unfolding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...
SARS-CoV-2 variants with enhanced transmissibility represent a serious threat to global health. Here...
The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines...
SARS-CoV-2 evolution threatens vaccine- and natural infection–derived immunity and the efficacy of t...
Accurate and reliable forecasting of emerging dominant severe acute respiratory syndrome coronavirus...
International audienceSignificance During the COVID pandemic, new severe acute respiratory syndrome ...
BackgroundA mechanistic understanding of the spread of SARS-CoV-2 and diligent tracking of ongoing m...
BackgroundA mechanistic understanding of the spread of SARS-CoV-2 and diligent tracking of ongoing m...
BackgroundA mechanistic understanding of the spread of SARS-CoV-2 and diligent tracking of ongoing m...
The continual evolution of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the ...
The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines...
The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines...
Predicting SARS-CoV-2 mutations is difficult, but predicting recurrent mutations driven by the host,...
The rise of SARS-CoV-2 variants and the history of outbreaks caused by zoonotic coronaviruses point ...
Scientists have made great efforts to understand the evolution of SARS-CoV-2 (Severe Acute Respirato...
Our understanding of the still unfolding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...
SARS-CoV-2 variants with enhanced transmissibility represent a serious threat to global health. Here...
The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines...