Image_4_Genomic landscape of lung adenocarcinomas in different races.jpeg

BackgroundLung adenocarcinoma is a molecularly heterogeneous disease. Several studies, including The Cancer Genome Atlas Research Network (TCGA) and Lung Cancer Mutation Consortium (LCMC), explored the genetic alterations among different ethnic groups. However, minority groups are often under-represented in these relevant studies and the genomic alterations among racial groups are not fully understood.MethodsWe analyze genomic characteristics among racial groups to understand the diversities and their impact on clinical outcomes.ResultsNative Americans had significantly higher rates of insertions and deletions than other races (PConclusionsThe tumor genomic landscape is significantly distinct in different races. This data would shed light on the understanding of molecular alterations and their impacts on clinical management in different lung cancer patients.