Internalization and mechanism of action of clostridial toxins in neurons.

Grumelli, C
Verderio, C
Pozzi, D
Rossetto, Ornella
Montecucco, Cesare
Matteoli, M.

Publication date

January 2005

DOI

10.1016/j.neuro.2004.12.012

Publisher

Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598

ISSN

0161-813X

Citation count (estimate)

Abstract

Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinum toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals

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Internalization and mechanism of action of clostridial toxins in neurons.

Abstract

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Internalization and mechanism of action of clostridial toxins in neurons.

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