Vitamin E intake from natural sources and head and neck cancer risk: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium

Edefonti, V
Hashibe, M
Parpinel, M
Ferraroni, M
Turati, F
Serraino, D
Matsuo, K
Olshan, A F
Zevallos, J P
Winn, D M
Moysich, K
Zhang, Z-F
Morgenstern, H
Levi, F
Kelsey, K
Mcclean, M
Bosetti, C
Schantz, S
Yu, G-P
Boffetta, P
Chuang, S-C
A Lee, Y-C
La Vecchia, C
Decarli, A

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Publication date

January 2015

DOI

10.1038/bjc.2015.149

Publisher

Springer Science and Business Media LLC

Abstract

BACKGROUND: Evidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited. METHODS: We used individual-level pooled data from 10 case-control studies (5959 cases and 12\u2009248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of non-alcohol energy-adjusted vitamin E intake. RESULTS: Intake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile...