Add to ORKGInternational audienceProteins containing one or more RNA Recognition Motif (RRM) domains perform important regulation functions through binding to specific RNA sequences. Our project is to help design new RRM proteins by providing data-driven rules and knowledge, based on the 3D structures of RRM domains. Protein domain classifications were screened to identify the most comprehensive set of RRM families for which one or more 3D structures are available. We created a master alignment for all available RRM 3D structures using Pfam (PF00076) seed alignment and the Kpax tool. Amino-acid properties and structural descriptors like torsion angles or accessibility were linked to the nucleotide-binding capacity at each position, and compared in RNA...
RNA molecules are attractive therapeutic targets because non-coding RNA molecules have increasingly ...
RNA molecules are able to bind proteins, DNA and other small or long RNAs using information at prima...
Recent advances in RNA sequencing technologies have greatly expanded our knowledge of the RNA landsc...
International audienceProteins containing one or more RNA Recognition Motif (RRM) domains perform im...
RNA recognition motifs (RRM) are the most prevalent class of RNA binding domains in eukaryotes. Thei...
RNA–protein interactions differ from DNA–protein interactions because of the central role of RNA sec...
RBPmotif web server (http://www.rnamotif.org) implements tools to identify binding preferences of RN...
Abstract Background RNA-binding proteins (RBPs) play vital roles in many processes in the cell. Diff...
MOTIVATION: RNA-binding proteins (RBPs) regulate every aspect of RNA metabolism and function. There ...
RNA-binding proteins (RBPs) are critical parts of the gene regulatory framework, but the vast majori...
his thesis examines the role of computational methods in identifying the motifs utilized by RNA bind...
<div><p>Interactions between protein and RNA play a key role in many biological processes in the gen...
textRNA recognition motifs (RRMs) are a ubiquitous class of proteins which bind RNA in a sequence-sp...
Recent progress in predicting RNA structure is moving towards filling the ‘gap ’ in 2D RNA structure...
RNA molecules participate actively in all aspects of gene expression, as information carriers, catal...
RNA molecules are attractive therapeutic targets because non-coding RNA molecules have increasingly ...
RNA molecules are able to bind proteins, DNA and other small or long RNAs using information at prima...
Recent advances in RNA sequencing technologies have greatly expanded our knowledge of the RNA landsc...
International audienceProteins containing one or more RNA Recognition Motif (RRM) domains perform im...
RNA recognition motifs (RRM) are the most prevalent class of RNA binding domains in eukaryotes. Thei...
RNA–protein interactions differ from DNA–protein interactions because of the central role of RNA sec...
RBPmotif web server (http://www.rnamotif.org) implements tools to identify binding preferences of RN...
Abstract Background RNA-binding proteins (RBPs) play vital roles in many processes in the cell. Diff...
MOTIVATION: RNA-binding proteins (RBPs) regulate every aspect of RNA metabolism and function. There ...
RNA-binding proteins (RBPs) are critical parts of the gene regulatory framework, but the vast majori...
his thesis examines the role of computational methods in identifying the motifs utilized by RNA bind...
<div><p>Interactions between protein and RNA play a key role in many biological processes in the gen...
textRNA recognition motifs (RRMs) are a ubiquitous class of proteins which bind RNA in a sequence-sp...
Recent progress in predicting RNA structure is moving towards filling the ‘gap ’ in 2D RNA structure...
RNA molecules participate actively in all aspects of gene expression, as information carriers, catal...
RNA molecules are attractive therapeutic targets because non-coding RNA molecules have increasingly ...
RNA molecules are able to bind proteins, DNA and other small or long RNAs using information at prima...
Recent advances in RNA sequencing technologies have greatly expanded our knowledge of the RNA landsc...