Add to ORKGTo investigate whether differential phosphorylation states of blood markers can identify LRRK2 Parkinson's disease (PD) patients, we assessed phospho(P)-Ser-935-LRRK2 and P-Ser-473-AKT levels in peripheral blood cells from G2019S LRRK2-associated PD patients (L2PD, n=31), G2019S LRRK2 non-manifesting carriers (L2NMC, n=26), idiopathic PD (iPD, n=25), and controls (n=40) (total n=122). We found no differences at P-Ser-935-LRRK2 between groups but detected a specific increase of P-Ser-473-AKT levels in all G2019S carriers, either L2PD or L2NMC, absent in iPD. Although insensitive to LRRK2 inhibition, our study identifies P-Ser-473-AKT as an endogenous candidate biomarker for peripheral inflammation in G2019S carriers using accessible blood ce...
Background: Leucine rich repeat kinase 2 (LRRK2) is a promising target for the treatment of Parkinso...
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are the most common known cause ...
Background: Mutations in LRRK2 gene represent the most common known genetic cause of Parkinson’s dis...
The purpose of this study was to investigate whether differential phosphorylation states of blood m...
A significant number of autosomal dominantly inherited Parkinson's disease (PD) cases are due to mut...
A significant number of autosomal dominantly inherited Parkinsons disease (PD) cases are due to muta...
Objective: The greatest unmet need in Parkinson’s disease (PD) are disease-modifying treatments. The...
Background: We aimed to determine if peripheral or central inflammatory cytokines are altered in hea...
Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of genetic ...
Despite several advances in the field, pharmacodynamic outcome measures reflective of LRRK2 kinase a...
After the discoveiy of kinase activating mutations in leucine-rich repeat kinase 2 (LRRK2) as associ...
Parkinson’s disease (PD) is the most common movement disorder worldwide. Approximately 10% of all PD...
PD is a neurodegenerative disorder, where the accumulation of α-SN aggregates is a central hallmark ...
Background: Leucine rich repeat kinase 2 (LRRK2) is a promising target for the treatment of Parkinso...
The commonest known cause of Parkinson's disease (PD) is the G2019S mutation of the LRRK2 gene, but ...
Background: Leucine rich repeat kinase 2 (LRRK2) is a promising target for the treatment of Parkinso...
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are the most common known cause ...
Background: Mutations in LRRK2 gene represent the most common known genetic cause of Parkinson’s dis...
The purpose of this study was to investigate whether differential phosphorylation states of blood m...
A significant number of autosomal dominantly inherited Parkinson's disease (PD) cases are due to mut...
A significant number of autosomal dominantly inherited Parkinsons disease (PD) cases are due to muta...
Objective: The greatest unmet need in Parkinson’s disease (PD) are disease-modifying treatments. The...
Background: We aimed to determine if peripheral or central inflammatory cytokines are altered in hea...
Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of genetic ...
Despite several advances in the field, pharmacodynamic outcome measures reflective of LRRK2 kinase a...
After the discoveiy of kinase activating mutations in leucine-rich repeat kinase 2 (LRRK2) as associ...
Parkinson’s disease (PD) is the most common movement disorder worldwide. Approximately 10% of all PD...
PD is a neurodegenerative disorder, where the accumulation of α-SN aggregates is a central hallmark ...
Background: Leucine rich repeat kinase 2 (LRRK2) is a promising target for the treatment of Parkinso...
The commonest known cause of Parkinson's disease (PD) is the G2019S mutation of the LRRK2 gene, but ...
Background: Leucine rich repeat kinase 2 (LRRK2) is a promising target for the treatment of Parkinso...
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are the most common known cause ...
Background: Mutations in LRRK2 gene represent the most common known genetic cause of Parkinson’s dis...