A genome-wide association study of total child psychiatric problems scores.
- Neumann, A
- Nolte, IM
- Pappa, I
- Ahluwalia, TS
- Pettersson, E
- Rodriguez, A
- Whitehouse, A
- Van Beijsterveldt, CEM
- Benyamin, B
- Hammerschlag, AR
- Helmer, Q
- Karhunen, V
- Krapohl, E
- Lu, Y
- Van der Most, PJ
- Palviainen, T
- St Pourcain, B
- Seppälä, I
- Suarez, A
- Vilor-Tejedor, N
- Tiesler, CMT
- Wang, C
- Wills, A
- Zhou, A
- Alemany, S
- Bisgaard, H
- Bønnelykke, K
- Davies, GE
- Hakulinen, C
- Henders, AK
- Hyppönen, E
- Stokholm, J
- Bartels, M
- Hottenga, J-J
- Heinrich, J
- Hewitt, J
- Keltikangas-Järvinen, L
- Korhonen, T
- Kaprio, J
- Lahti, J
- Lahti-Pulkkinen, M
- Lehtimäki, T
- Middeldorp, CM
- Najman, JM
- Pennell, C
- Power, C
- Oldehinkel, AJ
- Plomin, R
- Räikkönen, K
- Raitakari, OT
- Rimfeld, K
- Sass, L
- Snieder, H
- Standl, M
- Sunyer, J
- Williams, GM
- Bakermans-Kranenburg, MJ
- Boomsma, DI
- Van IJzendoorn, MH
- Hartman, CA
- Tiemeier, H
DOIAbstract
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects under...
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