(A) qPCR analysis of caspase-8 mRNA in scratch wounded keratinocytes, pre-treated with 5-Aza-2′-deoxycytidine (5A-dC) or DMSO (n = 4) (B), western blot analysis from keratinocytes transduced with scrambled RNA or DNMT3a shRNA (α-Tub = alpha-tubulin) (data are shown as mean ± SEM, P-values were calculated using 2-tailed t test (A), * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001, ns = P > 0.05). Data underlying the graphs can be found in S3A Fig and S3B Fig of S1 Raw Data. (TIF)</p
(A) Heat map of differentially regulated genes in control and scratch wounded keratinocytes. (B) Scr...
<p>Left: HEK001 keratinocytes were uninfected, or infected for 3 hours with ACAM-2000 at 20 MOI, in ...
Keratinocytes are non-professional immune cells contributing actively to innate immune responses par...
(A) ChIP-qPCR analysis to check DNMT3a and DNMT3b occupancy at caspase-8 promoter in control and scr...
<p>A) Immunohistochemistry was performed on <i>in vivo</i> wounded human skin four days post woundin...
(A) Model showing various potential protein molecules (red labels) involved in generating and/or sen...
International audienceWOUND HEALING INVOLVES SEVERAL STEPS: spreading of the cells, migration and pr...
(A) Representative image of unwounded/wound-distal skin section stained with DNMT3a, DAPI, and K5. (...
(A) DNMT3a and DAPI staining of wound proximal (B) Quantification and kinetics of DNMT3a localizati...
<p>A) Expression profiles. RNA was prepared from skin of K5-Cre (WT), <i>Socs1</i> cKO, and the dise...
(A) Levels of caspase-8 mRNA at different time points post-scratch wound (fold change) (n = 4). (B) ...
<p>(<b>A, B</b>) Primary human keratinocytes were transfected by p63 and MAPK-specific siRNAs. Expre...
<p>(<b>a</b>) Quantitative RT-PCR demonstrating the levels of ΔNp63, p73, TSLP, TSLPR and IL-7Rα mRN...
<p>Several TGFß inducible genes were measured in human primary keratinocytes in response to TGFß or ...
<p>(A) Primary keratinocytes analysed for p63 gene expression in the α6 integrin<sup>high+</sup>/CD4...
(A) Heat map of differentially regulated genes in control and scratch wounded keratinocytes. (B) Scr...
<p>Left: HEK001 keratinocytes were uninfected, or infected for 3 hours with ACAM-2000 at 20 MOI, in ...
Keratinocytes are non-professional immune cells contributing actively to innate immune responses par...
(A) ChIP-qPCR analysis to check DNMT3a and DNMT3b occupancy at caspase-8 promoter in control and scr...
<p>A) Immunohistochemistry was performed on <i>in vivo</i> wounded human skin four days post woundin...
(A) Model showing various potential protein molecules (red labels) involved in generating and/or sen...
International audienceWOUND HEALING INVOLVES SEVERAL STEPS: spreading of the cells, migration and pr...
(A) Representative image of unwounded/wound-distal skin section stained with DNMT3a, DAPI, and K5. (...
(A) DNMT3a and DAPI staining of wound proximal (B) Quantification and kinetics of DNMT3a localizati...
<p>A) Expression profiles. RNA was prepared from skin of K5-Cre (WT), <i>Socs1</i> cKO, and the dise...
(A) Levels of caspase-8 mRNA at different time points post-scratch wound (fold change) (n = 4). (B) ...
<p>(<b>A, B</b>) Primary human keratinocytes were transfected by p63 and MAPK-specific siRNAs. Expre...
<p>(<b>a</b>) Quantitative RT-PCR demonstrating the levels of ΔNp63, p73, TSLP, TSLPR and IL-7Rα mRN...
<p>Several TGFß inducible genes were measured in human primary keratinocytes in response to TGFß or ...
<p>(A) Primary keratinocytes analysed for p63 gene expression in the α6 integrin<sup>high+</sup>/CD4...
(A) Heat map of differentially regulated genes in control and scratch wounded keratinocytes. (B) Scr...
<p>Left: HEK001 keratinocytes were uninfected, or infected for 3 hours with ACAM-2000 at 20 MOI, in ...
Keratinocytes are non-professional immune cells contributing actively to innate immune responses par...