International audienceThe human immune system is in continuous interaction with environmental factors (pathogens, exercise, stress, pollutants, diet, vaccines, and therapeutics) that condition its efficiency by promoting or moderating multiple immune mechanisms. While the deleterious impact of external factors can be avoided or limited, the immune system itself grows weaker with age. Immune cells persist in the elderly, and the observed decline of cellular immunity is related to cellular senescence. Immunosenescence, which affects both T and B cells, erodes lymphocyte-dependent responses to vaccines and pathogens. Germinal centers (GCs), the organized lymphoid structures where B cells engage in affinity maturation, are regulated by follicul...
The function of the immune system declines with age, causing an increased occurrence and severity of...
Ageing is a complex process characterized by a general decline in physiological functions with incre...
Recognising invading foreign organisms, preventing their spread and ultimately clearing them from th...
International audienceThe human immune system is in continuous interaction with environmental factor...
Increasing age has been associated with an insufficient protection following vaccination and an incr...
During aging, the immune system undergoes changes that bring the tightly regulated immune system out...
SUMMARY Title: Age-associated Changes in the Germinal Centre Response upon Vaccination Name: Alyssa ...
Older people have reduced immune responses to infection and vaccination. B cell activation is key f...
B cells have a number of different roles in the immune response. Their excellent antigen presentatio...
The global population is ageing. Elderly people suffer from more severe infections than younger pers...
Major advances in preventing, delaying, or curing individual pathologies are responsible for an incr...
The investigation of immune senescence has uncovered many changes in B cell development, maintenance...
Ageing is often associated with a reduction in antibody-secreting cell formation and vaccine-induced...
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response...
The world population is undergoing a rapid expansion of older adults. Aging is associated with numer...
The function of the immune system declines with age, causing an increased occurrence and severity of...
Ageing is a complex process characterized by a general decline in physiological functions with incre...
Recognising invading foreign organisms, preventing their spread and ultimately clearing them from th...
International audienceThe human immune system is in continuous interaction with environmental factor...
Increasing age has been associated with an insufficient protection following vaccination and an incr...
During aging, the immune system undergoes changes that bring the tightly regulated immune system out...
SUMMARY Title: Age-associated Changes in the Germinal Centre Response upon Vaccination Name: Alyssa ...
Older people have reduced immune responses to infection and vaccination. B cell activation is key f...
B cells have a number of different roles in the immune response. Their excellent antigen presentatio...
The global population is ageing. Elderly people suffer from more severe infections than younger pers...
Major advances in preventing, delaying, or curing individual pathologies are responsible for an incr...
The investigation of immune senescence has uncovered many changes in B cell development, maintenance...
Ageing is often associated with a reduction in antibody-secreting cell formation and vaccine-induced...
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response...
The world population is undergoing a rapid expansion of older adults. Aging is associated with numer...
The function of the immune system declines with age, causing an increased occurrence and severity of...
Ageing is a complex process characterized by a general decline in physiological functions with incre...
Recognising invading foreign organisms, preventing their spread and ultimately clearing them from th...