(A) Enlarged transcriptome map of Ad5 E4 and E2A transcriptional units. Promoter transcription start sites are indicated with left-facing arrows, and cleavage and polyadenylation sites (pA) labeled with downward facing arrows. Novel E4-derived transcripts that terminate in E2A are highlighted in red. Ad5 mutant viruses dl1004 and dl355 contain deletions (indicated by hashed boxes) that remove most of the E4 region and splice donors (ΔE4) or a 14-base deletion inside E4orf6 that only abrogates E4orf6 expression (ΔE4orf6). (B) Reverse-transcriptase PCR on cDNA derived from Ad5-infection of A549 cells reveals characteristic bands of both E4orf6/Unk and E4orf6/DBP. L denotes DNA ladder and triangle indicates increasing cDNA concentration. (C) A...
Adenovirus is often associated with localized infections in areas such as the respiratory or intesti...
Adenovirus is a non-enveloped virus with an icosahedral capsid encompassing a double-stranded DNA ge...
<p>(Panel A) Schematic diagram of the wildtype Ad genome (not drawn to scale) showing locations of t...
(A) E4orf6 splice donor is recognized by base-pairing to the cellular U1 snRNP. Silent mutations sho...
AbstractGrowing awareness of the central role of the E4orf6 protein in regulating the infectious cyc...
(A) Domain map of DBP and E4orf6 open reading frames. HR: host range, NLS: nuclear localization sequ...
(A) A549 cells were infected with the indicated mutant adenoviruses for 24 hours and proteins were r...
The E4 region of human adenovirus type 2 is predicted to encode seven proteins as judged from its nu...
(A) The retroviral plasmid pLNE4 was designed to allow the expression of transgenes under the contro...
Adenovirus is a double stranded DNA virus known to cause illnesses such as respiratory infections an...
FUNCTION OF ADENOVIRUS EARLY REGION 4 PROTEINS IN RNA PROCESSING AND...
The human adenovirus type 5 E4 transcription unit has the potential to encode at least seven distinc...
The adenovirus type 5 E4orf6 protein plays many critical roles in the viral lifecycle. This thesis a...
Adenovirus is a double-stranded DNA virus that can cause self-limiting localized infections. Upon en...
The human adenovirus species C type 5 (HAdV-C5) early region 4 (E4) encodes several distinct polypep...
Adenovirus is often associated with localized infections in areas such as the respiratory or intesti...
Adenovirus is a non-enveloped virus with an icosahedral capsid encompassing a double-stranded DNA ge...
<p>(Panel A) Schematic diagram of the wildtype Ad genome (not drawn to scale) showing locations of t...
(A) E4orf6 splice donor is recognized by base-pairing to the cellular U1 snRNP. Silent mutations sho...
AbstractGrowing awareness of the central role of the E4orf6 protein in regulating the infectious cyc...
(A) Domain map of DBP and E4orf6 open reading frames. HR: host range, NLS: nuclear localization sequ...
(A) A549 cells were infected with the indicated mutant adenoviruses for 24 hours and proteins were r...
The E4 region of human adenovirus type 2 is predicted to encode seven proteins as judged from its nu...
(A) The retroviral plasmid pLNE4 was designed to allow the expression of transgenes under the contro...
Adenovirus is a double stranded DNA virus known to cause illnesses such as respiratory infections an...
FUNCTION OF ADENOVIRUS EARLY REGION 4 PROTEINS IN RNA PROCESSING AND...
The human adenovirus type 5 E4 transcription unit has the potential to encode at least seven distinc...
The adenovirus type 5 E4orf6 protein plays many critical roles in the viral lifecycle. This thesis a...
Adenovirus is a double-stranded DNA virus that can cause self-limiting localized infections. Upon en...
The human adenovirus species C type 5 (HAdV-C5) early region 4 (E4) encodes several distinct polypep...
Adenovirus is often associated with localized infections in areas such as the respiratory or intesti...
Adenovirus is a non-enveloped virus with an icosahedral capsid encompassing a double-stranded DNA ge...
<p>(Panel A) Schematic diagram of the wildtype Ad genome (not drawn to scale) showing locations of t...