A–D: Effects of weak Ih channel modulation on apical dendritic excitability in Almog and Hay model when a faster Ih inactivation was assumed. The experiments of Fig 4.6 were repeated using 4 times smaller time constants of Ih inactivation (τ∞) than in the original Hay and Almog models. See Fig 4.6 for details. E: Threshold current amplitudes for 2-ms square-pulse inputs at the apical dendrite at different distances from the soma using 4 times smaller time constants of Ih inactivation. Black: Hay-model control neuron, blue: Hay-model neuron with Ih blockage. The amplitudes are very similar to those with the original time constants (Fig 2G). (PDF)</p
We modeled two different mechanisms, a shunting conductance and a slow sodium inactivation, to test ...
A: Membrane potential (upper panels) and Ca2+-channel reversal potential (lower panels) time series ...
Abstract. Recent experimental and theoretical studies have found that active dendritic ionic current...
A–B: Predictions of the Almog model with a hot zone of Ca2+ channels for the threshold currents in c...
A–B: The frequency of APs (y-axis) in response to somatic DC of a given amplitude (x-axis) in Almog ...
A: Somatic membrane potential time courses according to the Almog model in response to 2-ms square-p...
A: Threshold current amplitudes for 2-ms square-pulse inputs at the apical dendrite according to Hay...
A–B: The morphology of the Almog (A) and Hay (B) model neurons. C–D: Membrane potential time courses...
A–C: Time courses of the membrane potential (A) and the activation (B) and inactivation (C) variable...
A: Predictions of the Almog model with a hot zone of Ca2+ channels. The upper left grid shows the th...
A: Almog- (top) and Hay-model (bottom) morphology color-coded according to distance from soma. Inset...
See Fig 2 for details. A: LVA Ca2+ channels blocked. B: HVA Ca2+ channels blocked. C: M-type K+ chan...
A–B: The Hay-model predictions for the AP threshold for spatially distributed apical dendritic stimu...
A–B: Illustration of the Ih channel conductance along the dendritic tree in Almog (A) and Hay (B) mo...
Abstract. The active dendritic conductances shape the input-output properties of many principal neur...
We modeled two different mechanisms, a shunting conductance and a slow sodium inactivation, to test ...
A: Membrane potential (upper panels) and Ca2+-channel reversal potential (lower panels) time series ...
Abstract. Recent experimental and theoretical studies have found that active dendritic ionic current...
A–B: Predictions of the Almog model with a hot zone of Ca2+ channels for the threshold currents in c...
A–B: The frequency of APs (y-axis) in response to somatic DC of a given amplitude (x-axis) in Almog ...
A: Somatic membrane potential time courses according to the Almog model in response to 2-ms square-p...
A: Threshold current amplitudes for 2-ms square-pulse inputs at the apical dendrite according to Hay...
A–B: The morphology of the Almog (A) and Hay (B) model neurons. C–D: Membrane potential time courses...
A–C: Time courses of the membrane potential (A) and the activation (B) and inactivation (C) variable...
A: Predictions of the Almog model with a hot zone of Ca2+ channels. The upper left grid shows the th...
A: Almog- (top) and Hay-model (bottom) morphology color-coded according to distance from soma. Inset...
See Fig 2 for details. A: LVA Ca2+ channels blocked. B: HVA Ca2+ channels blocked. C: M-type K+ chan...
A–B: The Hay-model predictions for the AP threshold for spatially distributed apical dendritic stimu...
A–B: Illustration of the Ih channel conductance along the dendritic tree in Almog (A) and Hay (B) mo...
Abstract. The active dendritic conductances shape the input-output properties of many principal neur...
We modeled two different mechanisms, a shunting conductance and a slow sodium inactivation, to test ...
A: Membrane potential (upper panels) and Ca2+-channel reversal potential (lower panels) time series ...
Abstract. Recent experimental and theoretical studies have found that active dendritic ionic current...