Additional file 1 of Peripheral blood transcriptomic clusters uncovered immune phenotypes of asthma

Additional file 1: Table S1. Baseline characteristics of the included asthmatics and non-asthmatics. BMI, body mass index; FeNO, fractional exhaled nitric oxide; FEF25-75, forced expiratory flow between 25–75%; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; PY, pack years; SD, standard deviation. Table S2. Difference in transcriptome expression between asthmatic patients and non-asthmatic subjects. If fold changes are upper than 1 (each cluster of asthmatics > non-asthmatics), then log2 fold change becomes positive. Table S3. Top 20 transcriptomes differentially expressed among three clusters in asthmatics. If fold changes are upper than 1 (preceding cluster > following cluster), then log2 fold change becomes positive. Table S4. Pre-specified genes associated with asthma pathogenesis among three clusters in asthmatics. If fold changes are upper than 1 (preceding cluster > following cluster), then log2 fold change becomes positive. Table S5. Linear regression analysis for transcriptome expression among three clusters in asthmatics and non-asthmatics. a Bonferroni correction was conducted. Table S6. Lung and gut microbiome abundance in asthma patients classified by different three clusters. B-H, Benjamini-Hochberg