CCT196969 treatment reduces tumour sphere growth in MBM cell lines in a dose-dependent manner.

(A) Representative phase-contrast microscopic images (20x objective) of the H1, H2 and H3 cell lines at different concentrations of CCT196969; untreated, 0.1 and 1 μM. Scale bars = 100 μm. (B) Representative viability curves of the 3 cell lines with the mean IC50 dose of the triplicates. (C) Mean tumour sphere volumes (in mm3) measured after 10 days exposure to different CCT196969 concentrations: untreated, 0.01, 0.05, 0.1 and 1 μM for the H1 and H2 cell lines, and untreated, 0.05, 0.1, 0.5 and 1 for the H3 cell line.