Feedback strength influence on fractional state probabilities and protein counts (related to Fig 3).

(A-B) Heatmap of average mRNA at 24 hours (A) and fractional promoter-state probabilities in the initial state (B) for a range of feedback strengths. All other parameters are set to BIR = 0.1 hr-1, BTR = 1 hr-1, PBR = PPRR = 10 hr-1. Data was generated by stochastic simulation for 1,000 cells for each parameter combination. The feedback terms K (half max) and A (amplification factor) were varied over 5 orders of magnitude. (C) Feedback strength calculated for varied K values and plotted versus protein. (PDF)