Raman and infrared microscopic study on the lipid redistribution in Alzheimer diseased murine tissue

The Alzheimer disease (AD) is the most common form of dementia. Several stages characterize the neurodegenerative process from the early AD to severe AD. During these stages, major structural and molecular changes will spread throughout the cerebral cortex. Here, we present Raman and Infrared microscopic evidences for the reorganization of phospholipids in brain tissue from AD diseased tissues of mice with severe AD. On the basis of the imaging results, it can be shown that the lipid concentration around the aggregates increases and decreases in the plaques. In addition, a change of the ratio of unsaturated to saturated lipids is found pointing towards a changed metabolism