miR-155 regulative network in FLT3 mutated acute myeloid leukemia
- Salemi, D
- Cammarata, G
- Agueli, C
- Augugliaro, L
- Corrado, C
- Bica. MG
- Raimondo, S
- Marfia, A
- Randazzo, V
- Dragotto, P
- Di Raimondo, F
- Alessandro, R
- Fabbiano, F
- Santoro, A
Publication date
January 2015
DOI Publisher
Elsevier BV ISSN
0145-2126 Citation count (estimate)
10Abstract
Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia
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