Additional file 1 of Auditory processing in rodent models of autism: a systematic review

Additional file 1: Supplementary Table 1. Primary research articles which passed the criteria for inclusion in the systematic review. Studies conducted using mouse models on the C57/Black6 background at an age over 3 months are indicated by an asterisk after the author name. Supplementary Table 2. Rodent models with auditory phenotypes described in this review. Gene names are formatted as in the cited papers, with alternate names for equivalent human genes used in SFARI gene in brackets where relevant. Supplementary Figure 1. The ascending auditory processing pathway with presumed changes in autism based on results from human studies. Excitatory (red) and inhibitory (blue) connections between structures along the pathway are illustrated along with the changes to these connections and the activity within areas in human autism studies. Connections are primarily ipsilateral unless otherwise stated. Responses in the superior olivary complex occur later, likely due to slower transmission from the cochlear nuclei. Responses in the inferior colliculus also occur later, but it is unclear whether it is input from the cochlear nuclei or the superior olivary complex, or both, which is delayed. Signals from the auditory thalamus take longer to reach the auditory cortex in human autism papers. There is decreased activity and increased latency (N1), and reduced gamma in the auditory cortex in human autism studies