γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the design of novel and highly innovative immunotherap...
In the last 10 years, cancer stem cells have interested the scientific community because this small ...
Abstract Background Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant...
Cancer – the “Emperor of all Maladies” is one of the most threatening diseases of our times. In one ...
\u3b3\u3b4 T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity aga...
: In recent years, research has focused on colorectal cancer to implement modern treatment approache...
Colon cancer comprises a small population of cancer stem cells (CSC) that is responsible for tumor m...
Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible ...
<div><p>Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is resp...
NKG2D, an activating receptor expressed on NK cells and T cells, is critically involved in tumor imm...
Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible ...
International audienceRecently, the inhibitory CD94/NKG2A receptor has joined the group of immune ch...
Cellular immunotherapy offers novel, safe, and effective routes to treating cancer. However, approac...
DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that is thought to...
Colon cancer is still one of the leading causes of cancer death worldwide. Although the host immune ...
n the last 10 years, cancer stem cells have interested the scienti c community because this small tu...
In the last 10 years, cancer stem cells have interested the scientific community because this small ...
Abstract Background Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant...
Cancer – the “Emperor of all Maladies” is one of the most threatening diseases of our times. In one ...
\u3b3\u3b4 T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity aga...
: In recent years, research has focused on colorectal cancer to implement modern treatment approache...
Colon cancer comprises a small population of cancer stem cells (CSC) that is responsible for tumor m...
Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible ...
<div><p>Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is resp...
NKG2D, an activating receptor expressed on NK cells and T cells, is critically involved in tumor imm...
Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible ...
International audienceRecently, the inhibitory CD94/NKG2A receptor has joined the group of immune ch...
Cellular immunotherapy offers novel, safe, and effective routes to treating cancer. However, approac...
DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that is thought to...
Colon cancer is still one of the leading causes of cancer death worldwide. Although the host immune ...
n the last 10 years, cancer stem cells have interested the scienti c community because this small tu...
In the last 10 years, cancer stem cells have interested the scientific community because this small ...
Abstract Background Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant...
Cancer – the “Emperor of all Maladies” is one of the most threatening diseases of our times. In one ...