A Protein-Interaction Array Inside a Living Cell
- Gandor S
- Reisewitz R
- Venkatachalapathy M
- Arrabito, Giuseppe Domenico
- Reibner R
- Schroeder H
- Ruf K
- Niemeyer C. M.
- Bastiaens P. I. H
- Dehmelt L.
DOIAbstract
Protein-interaction arrays were generated in living cells by the interaction of bait-presenting artificial receptor constructs (bait-PARCs) with micrometer-scaled antibody surface patterns (see figure). This method was applied to simultaneously monitor the interaction kinetics of a prey protein with two distinct bait proteins in individual living cells
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