The oligodendrocyte progenitors (OPCs) are at the front of the glial reaction to the traumatic brain injury. However, regulatory pathways steering the OPC reaction as well as the role of reactive OPCs remain largely unknown. Here, we compared a long-lasting, exacerbated reaction of OPCs to the adult zebrafish brain injury with a timely restricted OPC activation to identify the specific molecular mechanisms regulating OPC reactivity and their contribution to regeneration. We demonstrated that the influx of the cerebrospinal fluid into the brain parenchyma after injury simultaneously activates the toll-like receptor 2 (Tlr2) and the chemokine receptor 3 (Cxcr3) innate immunity pathways, leading to increased OPC proliferation and thereby exace...
Adult mammalian brain, including humans, has rather limited addition of new neurons and poor regener...
Brain injury and neurodegenerative disorders such as Alzheimer's and Parkinson's disease, multiple s...
Adult mammalian brain, including humans, has rather limited addition of new neurons and poor regener...
The oligodendrocyte progenitors (OPCs) are at the front of the glial reaction to the traumatic brain...
Reactive glia, including astroglia and oligodendrocyte progenitors (OPCs) are at the core of the rea...
International audienceIn contrast to mammals, the adult zebrafish brain shows neurogenic activity in...
Neurodegenerative disorders, characterized by progressive neuronal loss, eventually lead to function...
The mammalian central nervous system is not able to regenerate neurons lost upon injury. In contrast...
How diverse adult stem and progenitor populations regenerate tissue following damage to the brain is...
Poor recovery of neuronal functions is one of the most common healthcare challenges for patients wit...
BACKGROUND: Unlike mammals, zebrafish exhibits extensive neural regeneration after injury in adult s...
SUMMARY Neural stem cells in the subventricular zone (SVZ) of the adult mammalian forebrain are a po...
In the adult zebrafish brain, life-long proliferation and neurogenesis occur in several ventricular ...
During embryonic neural development, Radial Glia (RG) cells act as Neural Stem Cells (NSCs), generat...
Abstract Background In contrast to mammals, zebrafish have the capacity to regenerate retinal neuron...
Adult mammalian brain, including humans, has rather limited addition of new neurons and poor regener...
Brain injury and neurodegenerative disorders such as Alzheimer's and Parkinson's disease, multiple s...
Adult mammalian brain, including humans, has rather limited addition of new neurons and poor regener...
The oligodendrocyte progenitors (OPCs) are at the front of the glial reaction to the traumatic brain...
Reactive glia, including astroglia and oligodendrocyte progenitors (OPCs) are at the core of the rea...
International audienceIn contrast to mammals, the adult zebrafish brain shows neurogenic activity in...
Neurodegenerative disorders, characterized by progressive neuronal loss, eventually lead to function...
The mammalian central nervous system is not able to regenerate neurons lost upon injury. In contrast...
How diverse adult stem and progenitor populations regenerate tissue following damage to the brain is...
Poor recovery of neuronal functions is one of the most common healthcare challenges for patients wit...
BACKGROUND: Unlike mammals, zebrafish exhibits extensive neural regeneration after injury in adult s...
SUMMARY Neural stem cells in the subventricular zone (SVZ) of the adult mammalian forebrain are a po...
In the adult zebrafish brain, life-long proliferation and neurogenesis occur in several ventricular ...
During embryonic neural development, Radial Glia (RG) cells act as Neural Stem Cells (NSCs), generat...
Abstract Background In contrast to mammals, zebrafish have the capacity to regenerate retinal neuron...
Adult mammalian brain, including humans, has rather limited addition of new neurons and poor regener...
Brain injury and neurodegenerative disorders such as Alzheimer's and Parkinson's disease, multiple s...
Adult mammalian brain, including humans, has rather limited addition of new neurons and poor regener...