Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DALI Study
- Roberts, J.
- Lipman, J.
- Starr, T.
- Wallis, S.
- Paul, S.
- Ribas, A.
- De Waele, J.
- Decrop, L.
- Spapen, H.
- Wauters, J.
- Dugernier, T.
- Jorens, P.
- Dapper, I.
- De Backer, D.
- Taccone, F.
- Rello, J.
- Ruano, L.
- Afonso, E.
- Alvarez Lerma, F.
- Gracia Arnillas, M.
- Fern\ue1ndez, F.
- Feijoo, N.
- Bardolet, N.
- Rovira, A.
- Garro, P.
- Colon, D.
- Castillo, C.
- Fernado, J.
- Lopez, M.
- Fernandez, J.
- Arribas, A.
- Teja, J.
- Ots, E.
- Montejo, J.
- Catalan, M.
- Prieto, I.
- Gonzalo, G.
- Galvan, B.
- Blasco, M.
- Meyer, E.
- Nogal, F.
- Vidaur, L.
- Sebastian, R.
- Garde, P.
- Velasco Mdel, M.
- Crespo, R.
- Esperatti, M.
- Torres, A.
- Montravers, P.
- Baldesi, O.
- Dupont, H.
- Mahjoub, Y.
- Lasocki, S.
- Constantin, J.
- Payen, J.
- Martin, C.
- Albanese, J.
- Malledant, Y.
- Pottecher, J.
- Lefrant, J.
- Jaber, S.
- Joannes Boyau, O.
- Orban, C.
- Ostermann, M.
- Mckenzie, C.
- Berry, W.
- Smith, J.
- Lei, K.
- Rubulotta, F.
- Gordon, A.
- Brett, S.
- Stotz, M.
- Templeton, M.
- Rhodes, A.
- Ebm, C.
- Moran, C.
- Kaukonen, K.
- Pettil\ue4, V.
- Dimopoulos, G.
- Koulenti, D.
- Xristodoulou, A.
- Theodorou, V.
- Kouliatsis, G.
- Sertaridou, E.
- Anthopoulos, G.
- Choutas, G.
- Rantis, T.
- Karatzas, S.
- Balla, M.
- Papanikolaou, M.
- Myrianthefs, P.
- Gavala, A.
- Fildisis, G.
- Koutsoukou, A.
- Kyriakopoulou, M.
- Petrochilou, K.
- Kompoti, M.
- Michalia, M.
- Clouva Molyvdas, F.
- Gkiokas, G.
- Nikolakopoulos, F.
- Psychogiou, V.
- Malliotakis, P.
- Akoumianaki, E.
- Lilitsis, E.
- Koulouras, V.
- Nakos, G.
- Kalogirou, M.
- Komnos, A.
- Zafeiridis, T.
- Chaintoutis, C.
- Arvaniti, K.
- Matamis, D.
- Chaintoutis, C.
- Kydona, C.
- Gritsi Gerogianni, N.
- Giasnetsova, T.
- Giannakou, M.
- Soultati, I.
- Chytas, I.
- Antoniadou, E.
- Antipa, E.
- Lathyris, D.
- Koukoubani, T.
- Paraforou, T.
- Spiropoulou, K.
- Bekos, V.
- Spring, A.
- Kalatzi, T.
- Nikolaou, H.
- Laskou, M.
- Strouvalis, I.
- Aloizos, S.
- Kapogiannis, S.
- Soldatou, O.
- Bassetti, M.
- Adembri, C.
- Villa, G.
- Giarratano, A.
- Raineri, S.
- Cortegiani, A.
- Montalto, F.
- Strano, M.
- Ranieri, V.
- Sandroni, C.
- De Pascale, G.
- Molin, A.
- Pelosi, P.
- Montagnani, L.
- Urbino, R.
- Mastromauro, I.
- Derosa, F.
- Ranieri, V.
- Cardoso, T.
- Afonso, S.
- Gon\ue7alves Pereira, J.
- Baptista, J.
- Akova, M.
- 6zveren, A.
DOIAbstract
The aims of this study were to describe the variability in protein binding of teicoplanin in critically ill patients as well as the number of patients achieving therapeutic target concentrations. This report is part of the multinational pharmacokinetic DALI Study. Patients were sampled on a single day, with blood samples taken both at the midpoint and the end of the dosing interval. Total and unbound teicoplanin concentrations were assayed using validated chromatographic methods. The lower therapeutic range of teicoplanin was defined as total trough concentrations from 10 to 20 mg/L and the higher range as 10\u201330mg/L. Thirteen critically ill patients were available for analysis. The following are the median (interquartile range) total a...
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