Internal lubrication can be associated with reduced tabletability. Deformation mechanism, lubricant type, lubricant blending time and paddle speed (PS) of the forced feeder are known to be influenceable factors. This study investigated the effect of lubricant blending time and PS of forced feeders on the tensile strength of lubricated microcrystalline cellulose (MCC) and lactose tablets. Magnesium stearate (MgSt), sodium stearyl fumarate (SSF) and stearic acid (SA) were used as lubricants. Tablets were produced on a compaction simulator and a rotary tablet press to investigate lubricant sensitivity during upscaling. Lubricant sensitivity was found higher for MCC compared to lactose which was attributed to the higher plasticity of MCC. The r...
The thesis studied tensile strength, disintegration time of tablets and energy profile of compressio...
The objective of this study was to investigate the effects of conventional lubricants including a ne...
The aim of this work was to compare two spray-dried lactoses Flowlac® 100 and SuperTab® 14SD from th...
The majority of tablets manufactured contain lubricants to reduce friction during ejection. However,...
The aim of this study was to evaluate the effect of the type of lubricant, its concentration and mix...
This paper describes the differences in compaction properties between microcrystalline cellulose (MC...
Context: The negative impact of magnesium stearate (MgSt) on the hardness of tablets is a well-known...
The thesis studies mechanical strenght and disintegration time of tablets from two types of Microcel...
ABSTRACT: By using five different sieve sizes of ascorbic acid granules, affects of granule sizes on...
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical tec...
In the work is studied mechanical strength and disintegration time of tablets prepared by direct com...
It is generally known that hydrophobic lubricants such as magnesium stearate can have a strong negat...
Tablet is the most common pharmaceutical dosage form in drug industry. It is classified as a solid d...
The study described in this paper was concerned with the susceptibility to lubrication with magnesiu...
The study evaluates the micronized poloxamers Lμtrol® micro 127 (poloxamer 407) and Lμtrol® micro 68...
The thesis studied tensile strength, disintegration time of tablets and energy profile of compressio...
The objective of this study was to investigate the effects of conventional lubricants including a ne...
The aim of this work was to compare two spray-dried lactoses Flowlac® 100 and SuperTab® 14SD from th...
The majority of tablets manufactured contain lubricants to reduce friction during ejection. However,...
The aim of this study was to evaluate the effect of the type of lubricant, its concentration and mix...
This paper describes the differences in compaction properties between microcrystalline cellulose (MC...
Context: The negative impact of magnesium stearate (MgSt) on the hardness of tablets is a well-known...
The thesis studies mechanical strenght and disintegration time of tablets from two types of Microcel...
ABSTRACT: By using five different sieve sizes of ascorbic acid granules, affects of granule sizes on...
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical tec...
In the work is studied mechanical strength and disintegration time of tablets prepared by direct com...
It is generally known that hydrophobic lubricants such as magnesium stearate can have a strong negat...
Tablet is the most common pharmaceutical dosage form in drug industry. It is classified as a solid d...
The study described in this paper was concerned with the susceptibility to lubrication with magnesiu...
The study evaluates the micronized poloxamers Lμtrol® micro 127 (poloxamer 407) and Lμtrol® micro 68...
The thesis studied tensile strength, disintegration time of tablets and energy profile of compressio...
The objective of this study was to investigate the effects of conventional lubricants including a ne...
The aim of this work was to compare two spray-dried lactoses Flowlac® 100 and SuperTab® 14SD from th...