atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
- Fournier Le Ray, L.
- Aubry, A.
- Sougakoff, W.
- Revest, M.
- Robert, J.
- Bonnet, I.
- Veziris, Nicolas
- Morel, F.
Publication date
January 2022
DOI Publisher
Centers for Disease Control and Prevention (CDC)Abstract
International audienceWe report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance. © 2022 Centers for Disease Control and Prevention (CDC). All rights reserved
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