The Atrial Natriuretic Peptide Genetic Variant Rs5068 Is Associated With a Favorable Cardiometabolic Phenotype in a Mediterranean Population

Cannone, V.
Cefalu', A.
Noto, D.
Scott, C.
Bailey, K.
Cavera, G.
Pagano, M.
Sapienza, M.
Averna, M.
Burnett, J.

Open link

Publication date

January 2013

DOI

10.2337/dc12-2337

Publisher

American Diabetes Association

ISSN

0149-5992

Citation count (estimate)

Abstract

OBJECTIVEWe hypothesized that the minor allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a general Mediterranean population.RESEARCH DESIGN AND METHODSWe genotyped a random sample of the residents of Ventimiglia di Sicilia, Sicily, for rs5068.RESULTSGenotype frequencies of rs5068 are AA, 93.5%; AG, 6.4%; and GG, 0.1%. All subsequent analyses are AA versus AG+GG. After adjusting for age and sex, the minor G allele is associated with lower BMI (estimate [SE]: -1.7 kg/m(2) [0.8], P = 0.04). In the AG+GG group, males with HDL cholesterol levels <40 mg/dL are less frequent (P = 0.05) and obesity tends to be less prevalent (P = 0.07). Importantly, the G allele is ass...