Preclinical analysis of drug efficacy is critical for drug development. However, conventional bulk-cell assays statically assess the mean population behavior, lacking resolution on drugescaping cells. Inaccurate estimation of efficacy can lead to overestimation of compounds, whose efficacy will not be confirmed in the clinic, or lead to rejection of valuable candidates. Time-lapse microfluidic microscopy is a powerful approach to characterize drugs at high spatiotemporal resolution, but hard to apply on a large scale. Here we report the development of a microfluidic platform based on a pneumatic operating principle, which is scalable and compatible with long-term live-cell imaging and with simultaneous analysis of different drug concentrati...
We present a microfluidic device to expose cancer cells to a dynamic, in vivo-like concentration pro...
Antibiotic resistance has been one of the biggest threats to global health. Despite the available pr...
Human response to drugs and environmental chemicals is often dramatically different from predictions...
As one of the world's most devastating diseases, tuberculosis is a global health crisis, with over t...
Phenotypic heterogeneity in bacterial populations is thought to contribute to a number of important ...
Thesis (Ph.D.)--Boston UniversityMycobacterium tuberculosis (MTB), the causative agent of tuberculos...
Understanding cellular behavior in a quantitative manner will provide valuable information to reveal...
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2017.Cata...
The impact of cellular individuality on host-microbe interactions is increasingly appreciated but st...
Tuberculosis (TB) remains a global healthcare crisis, with an estimated 5.8 million new cases and 1....
International audienceStudies on cell-to-cell phenotypic variation in microbial populations, with in...
Antibiotic resistance has been one of the biggest threats to global health. Despite the available pr...
ABSTRACT Antimicrobial resistance presents one of the most significant threats to human health, with...
Antimicrobial resistance presents one of the most significant threats to human health, with the emer...
Single cell analysis (SCA) has gained increased popularity for elucidating cellular heterogeneity at...
We present a microfluidic device to expose cancer cells to a dynamic, in vivo-like concentration pro...
Antibiotic resistance has been one of the biggest threats to global health. Despite the available pr...
Human response to drugs and environmental chemicals is often dramatically different from predictions...
As one of the world's most devastating diseases, tuberculosis is a global health crisis, with over t...
Phenotypic heterogeneity in bacterial populations is thought to contribute to a number of important ...
Thesis (Ph.D.)--Boston UniversityMycobacterium tuberculosis (MTB), the causative agent of tuberculos...
Understanding cellular behavior in a quantitative manner will provide valuable information to reveal...
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2017.Cata...
The impact of cellular individuality on host-microbe interactions is increasingly appreciated but st...
Tuberculosis (TB) remains a global healthcare crisis, with an estimated 5.8 million new cases and 1....
International audienceStudies on cell-to-cell phenotypic variation in microbial populations, with in...
Antibiotic resistance has been one of the biggest threats to global health. Despite the available pr...
ABSTRACT Antimicrobial resistance presents one of the most significant threats to human health, with...
Antimicrobial resistance presents one of the most significant threats to human health, with the emer...
Single cell analysis (SCA) has gained increased popularity for elucidating cellular heterogeneity at...
We present a microfluidic device to expose cancer cells to a dynamic, in vivo-like concentration pro...
Antibiotic resistance has been one of the biggest threats to global health. Despite the available pr...
Human response to drugs and environmental chemicals is often dramatically different from predictions...