Intestinal passive absorption of hydrosoluble compounds by sparrows: effect of molecular size and luminal nutrients
- Chediack, Juan Gabriel
- Caviedes Vidal, Enrique Juan Raul
- Fasulo, Sara Veronica
- Yamin, L. J.
- Karasov, William
DOIAbstract
We tested predictions that: (1) absorption of water-soluble probes decreases with increasing molecular size, consistent with movement through effective pores in epithelia, and (2) absorption of probes is enhanced when measured in the presence of luminal nutrients, as predicted for paracellular solvent drag. Probes (L-arabinose, L-rhamnose, perseitol, lactulose; MW 150.1–342.3 Da) were gavaged in nonanesthetized House sparrows (Passer domesticus), or injected into the pectoralis, and serially measured in plasma. Bioavailability was calculated as F=AUC by gavage/AUC by injection, where AUC is the area under the curve of plasma probe concentration vs. time. Consistent with predictions, F declined with probe size by 75% from the smallest to the...
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