Add to ORKGMulticellular organisms coordinate the systemic response to stress. We have shown that in C. elegans the acute-stress response activates neurons that release tyramine (TA), the invertebrate analog of adrenaline/noradrenaline. TA stimulates the DAF-2/Insulin/IGF-1 pathway and precludes the nuclear translocation of the DAF-16/FOXO transcription factor through the activation of an adrenergic-like receptor TYRA-3 in the intestine. In contrast, environmental long-term stressors reduce TA release allowing the induction of FOXO-dependent cytoprotective genes. However, how the insuline and tyraminergic pathway are linked is unknown. We here found that genetic silencing of an insulin like-peptide (ILP) (INS-3) increases the resistance to thermal and...
During ischemic stroke, malfunction of excitatory amino acid transporters and reduced synaptic clear...
2015-07-09The Nrf2 transcription factor plays a critical role in mediating adaptive responses to cel...
During ischemic stroke, malfunction of excitatory amino acid transporters and reduced synaptic clear...
An animal’s stress response requires different adaptive strategies depending on the nature and durat...
An animal\u27s stress response requires different adaptive strategies depending on the nature and du...
Chronic stress disrupts insulin signaling, predisposing human populations to diabetes, cardiovascula...
To survive, animals must adapt to a complex and challenging world in a way that is flexible and resp...
An attack, or even the perception of a predator elicits a rapid “fight-or-flight” response to enhanc...
In C. elegans, expression of the UPRER transcription factor xbp-1s in neurons cell non-autonomously ...
Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a...
Neurotransmitters relay signals within the brain and to peripheral tissues, allowing communication b...
The insulin/IGF-1 signaling pathway plays a critical role in stress resistance and longevity, but th...
<div><p>The insulin/IGF-1 signaling pathway plays a critical role in stress resistance and longevity...
Insulin-like signaling (ILS) regulates metabolism, growth, development and lifespan in both vertebra...
During ischemic stroke, malfunction of excitatory amino acid transporters and reduced synaptic clear...
During ischemic stroke, malfunction of excitatory amino acid transporters and reduced synaptic clear...
2015-07-09The Nrf2 transcription factor plays a critical role in mediating adaptive responses to cel...
During ischemic stroke, malfunction of excitatory amino acid transporters and reduced synaptic clear...
An animal’s stress response requires different adaptive strategies depending on the nature and durat...
An animal\u27s stress response requires different adaptive strategies depending on the nature and du...
Chronic stress disrupts insulin signaling, predisposing human populations to diabetes, cardiovascula...
To survive, animals must adapt to a complex and challenging world in a way that is flexible and resp...
An attack, or even the perception of a predator elicits a rapid “fight-or-flight” response to enhanc...
In C. elegans, expression of the UPRER transcription factor xbp-1s in neurons cell non-autonomously ...
Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a...
Neurotransmitters relay signals within the brain and to peripheral tissues, allowing communication b...
The insulin/IGF-1 signaling pathway plays a critical role in stress resistance and longevity, but th...
<div><p>The insulin/IGF-1 signaling pathway plays a critical role in stress resistance and longevity...
Insulin-like signaling (ILS) regulates metabolism, growth, development and lifespan in both vertebra...
During ischemic stroke, malfunction of excitatory amino acid transporters and reduced synaptic clear...
During ischemic stroke, malfunction of excitatory amino acid transporters and reduced synaptic clear...
2015-07-09The Nrf2 transcription factor plays a critical role in mediating adaptive responses to cel...
During ischemic stroke, malfunction of excitatory amino acid transporters and reduced synaptic clear...