Add to ORKGThe active form of vitamin D3 , calcitriol, has been shown to display antitumoral effects on various types of cancer. However, hypercal- cemia is observed when effective antitumoral doses of calcitriol are employed, thus precluding its therapeutic application. In collabora- tion with the laboratory of Organic Chemistry of the University of Vigo we synthesized an analogue of calcitriol, called ML-344, in order to obtain a compound that retain or even increase the anti- tumoral activity but prevent the side effects. In this work we aimed to evaluate the biological effects of ML-344 by employing in vitro, in vivo and in silico assays. We demonstrated that the analogue exerts a significant decrease in the viability of different cancer cell line...
The active metabolite of vitamin D, 1α, 25 dihydroxyvitamin D3 (calcitriol) is classically known to ...
A new vitamin D2 analogue was synthesized using the Julia-Kocienski olefination. It has antiprolifer...
BACKGROUND:Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hy...
Calcitriol analogs have shown promising potential as compounds to be used in cancer chemotherapy. Th...
The active form of vitamin D3, calcitriol, is a potent antiproliferative compound. However, when eff...
Glioblastoma multiforme (GBM) is the worst and most common brain tumor, characterized by high prolif...
The active form of vitamin D3, calcitriol, plays a major role in maintaining calcium/phosphate homeo...
Background: 1α,25-dihydroxy vitamin D3 (calcitriol) shows potent growth-inhibitory properties on dif...
Vitamin D analogues EM1 and UVB1 have demonstrated antitumor effects in preclinical studies employin...
The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate ho...
Background Calcitriol (D) or 1,25(OH)2D3 inhibits the growth of several tumor cells including breast...
Tumor associated macrophages (Mɸ) orchestrate the different stages of tumor development. They are ab...
Triple negative breast cancer (TNBC) does not respond to current targeted therapies as it lacks the ...
Since decades, researchers have been intrigued by 1α,25-dihydroxy vitamin D3 (calcitriol) in variou...
Since decades, researchers have been intrigued by 1α,25-dihydroxy vitamin D3 (calcitriol) in variou...
The active metabolite of vitamin D, 1α, 25 dihydroxyvitamin D3 (calcitriol) is classically known to ...
A new vitamin D2 analogue was synthesized using the Julia-Kocienski olefination. It has antiprolifer...
BACKGROUND:Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hy...
Calcitriol analogs have shown promising potential as compounds to be used in cancer chemotherapy. Th...
The active form of vitamin D3, calcitriol, is a potent antiproliferative compound. However, when eff...
Glioblastoma multiforme (GBM) is the worst and most common brain tumor, characterized by high prolif...
The active form of vitamin D3, calcitriol, plays a major role in maintaining calcium/phosphate homeo...
Background: 1α,25-dihydroxy vitamin D3 (calcitriol) shows potent growth-inhibitory properties on dif...
Vitamin D analogues EM1 and UVB1 have demonstrated antitumor effects in preclinical studies employin...
The active form of vitamin D3, 1α,25(OH)2D3, plays a major role in maintaining calcium/phosphate ho...
Background Calcitriol (D) or 1,25(OH)2D3 inhibits the growth of several tumor cells including breast...
Tumor associated macrophages (Mɸ) orchestrate the different stages of tumor development. They are ab...
Triple negative breast cancer (TNBC) does not respond to current targeted therapies as it lacks the ...
Since decades, researchers have been intrigued by 1α,25-dihydroxy vitamin D3 (calcitriol) in variou...
Since decades, researchers have been intrigued by 1α,25-dihydroxy vitamin D3 (calcitriol) in variou...
The active metabolite of vitamin D, 1α, 25 dihydroxyvitamin D3 (calcitriol) is classically known to ...
A new vitamin D2 analogue was synthesized using the Julia-Kocienski olefination. It has antiprolifer...
BACKGROUND:Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hy...