Effect of Tocilizumab on LDL and HDL Characteristics in Patients with Rheumatoid Arthritis. An Observational Study
- Pierini, Florencia S.
- Botta, Eliana Elizabeth
- Soriano Guppy, Enrique Roberto
- Martin, Maximiliano Emanuel
- Boero, Laura Estela
- Meroño, Tomás
- Saez, María Soledad
- Lozano Chiappe, Ezequiel Silvano
- Cerda, Osvaldo
- Citera, Gustavo
- Gandino, Ignacio
- Rosa, Javier
- Sorroche, Patricia
- Kontush, Anatol
- Brites, Fernando
DOIAbstract
Background In patients with rheumatoid arthritis (RA), qualitative alterations of low and high-density lipoproteins (LDL and HDL, respectively) might partially explain their increased cardiovascular risk. Tocilizumab has been associated with an increase in lipids, including triglyceride (TG) and cholesterol levels. The aim of this study is to evaluate the effect of tocilizumab on certain LDL and HDL characteristics (oxidized LDL levels, HDL-associated enzymes, chemical composition of both total HDL and HDL3c subpopulation, and their capacity to promote cellular cholesterol efflux) at baseline and 3 months after the start of treatment in patients with RA. Methods Twenty-eight RA patients (ACR/EULAR 2010 criteria) with indication of treatment...
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