Elucidating the mechanism of action of alpha-1-antitrypsin using retinal pigment epithelium cells exposed to high glucose: Potential use in diabetic retinopathy
- Potilinski, María Constanza
- Ortiz, Gustavo Alfredo
- Salica, Juan Pablo
- Lopez, Emiliano Sebastian
- Fernández Acquier, Mariano
- Chuluyan, Hector Eduardo
- Gallo, Juan Eduardo Maria
DOIAbstract
Background: Alpha-1-antitrypsin is a protein involved in avoidance of different processes that are seen in diabetic retinopathy pathogenesis. These processes include apoptosis, extracellular matrix remodeling and damage of vessel walls and capillaries. Furthermore, because of its anti-inflammatory effects, alpha-1-antitrypsin has been proposed as a possible therapeutic approach for diabetic retinopathy. Our group tested alpha-1-antitrypsin in a type 1 diabetes mouse model and observed a reduction of inflammation and retinal neurodegeneration. Thus, shedding light on the mechanism of action of alpha-1-antitrypsin at molecular level may explain how it works in the diabetic retinopathy context and show its potential for use in other retinal di...
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