Solid tumors are comprised of multiple cell types which communicate and work together to promote tumor progression. Advances in the treatment of solid tumors have armed clinicians with more efficacious pharmacologic agents and combinations. However, a focus on drug adjuvants in the treatment of solid cancer has left gaps in knowledge regarding non-pharmacologic treatment adjuvants, like aerobic exercise. The current dissertation investigates pharmacologic and non-pharmacologic based approaches to remodel the solid tumor microenvironment landscape and alter therapeutic efficacy. We disassemble compartments of the tumor microenvironment, including tumor vasculature and immune infiltrate, using mouse models and single cell techniques, to eluci...
Exercise has a wide range of systemic effects. In animal models, repeated exertion reduces malignant...
AbstractTumor cell extravasation into the brain requires passage through the blood–brain barrier, wh...
Background: Obesity, an increasingly prevalent health problem, is a major risk factor for recurrenc...
<p>Over the past decade, exercise has gained increasing attention from both clinicians and patients ...
Immunity in the tumor microenvironment plays a central role in tumor development. Cytotoxic immune c...
Exercise has been shown to improve postischemia perfusion of normal tissues; we investigated whether...
The role of physical exercise for the maintenance of human health, for the prevention and cure of me...
Background: Aerobic exercise has been shown to slow tumor progression in rodents and humans, but the...
The risk for breast cancer is significantly reduced in persons who engage in greater amounts of phys...
Tumor cell extravasation into the brain requires passage through the blood-brain barrier (BBB). Ther...
Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms behind this p...
Immune checkpoint inhibition (ICI) has revolutionized cancer therapy. However, response to ICI is of...
Tumor cell extravasation into the brain requires passage through the blood-brain barrier (BBB). Ther...
Targeted therapies aimed at tumor vasculature are utilized in combination with chemotherapy to impro...
Funder: Vetenskapsrådet; FundRef: http://dx.doi.org/10.13039/501100004359Funder: Cancerfonden; FundR...
Exercise has a wide range of systemic effects. In animal models, repeated exertion reduces malignant...
AbstractTumor cell extravasation into the brain requires passage through the blood–brain barrier, wh...
Background: Obesity, an increasingly prevalent health problem, is a major risk factor for recurrenc...
<p>Over the past decade, exercise has gained increasing attention from both clinicians and patients ...
Immunity in the tumor microenvironment plays a central role in tumor development. Cytotoxic immune c...
Exercise has been shown to improve postischemia perfusion of normal tissues; we investigated whether...
The role of physical exercise for the maintenance of human health, for the prevention and cure of me...
Background: Aerobic exercise has been shown to slow tumor progression in rodents and humans, but the...
The risk for breast cancer is significantly reduced in persons who engage in greater amounts of phys...
Tumor cell extravasation into the brain requires passage through the blood-brain barrier (BBB). Ther...
Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms behind this p...
Immune checkpoint inhibition (ICI) has revolutionized cancer therapy. However, response to ICI is of...
Tumor cell extravasation into the brain requires passage through the blood-brain barrier (BBB). Ther...
Targeted therapies aimed at tumor vasculature are utilized in combination with chemotherapy to impro...
Funder: Vetenskapsrådet; FundRef: http://dx.doi.org/10.13039/501100004359Funder: Cancerfonden; FundR...
Exercise has a wide range of systemic effects. In animal models, repeated exertion reduces malignant...
AbstractTumor cell extravasation into the brain requires passage through the blood–brain barrier, wh...
Background: Obesity, an increasingly prevalent health problem, is a major risk factor for recurrenc...