Expanding the scope of strained-alkyne chemistry: a protection-deprotection strategy via the formation of a dicobalt-hexacarbonyl complex

7A protection-deprotection strategy for strained alkynes used for bioorthogonal chemistry is reported. A strained alkyne can be protected with dicobalt-octacarbonyl and we demonstrate for the first time that a strained alkyne can be re-formed and isolated under mild reaction conditions for further bioorthogonal reactivity. The protection-deprotection strategy herein reported will expand the versatility of strained alkynes for the preparation of substrates in chemical biology and materials applications.nonenoneGobbo P; Romagnoli T; Barbon SM; Price JT; Keir J; Gilroy JB; Workentin MSGobbo, P; Romagnoli, T; Barbon, Sm; Price, Jt; Keir, J; Gilroy, Jb; Workentin, M