A nationwide study on Sydenham's chorea: Clinical features, treatment and prognostic factors: A multicenter cohort study on Sydenham's chorea
- Orsini A.
- Foiadelli T.
- Magistrali M.
- Carli N.
- Bagnasco I.
- Dassi P.
- Verrotti A.
- Marcotulli D.
- Canavese C.
- Nicita F.
- Capuano A.
- Marra C.
- Fetta A.
- Nosadini M.
- Sartori S.
- Papa A.
- Viri M.
- Greco F.
- Pavone P.
- Simonini G.
- Matricardi S.
- Siquilini S.
- Marchese F.
- De Grandis E.
- Brunenghi B. M.
- Malattia C.
- Bassanese F.
- Bergonzini P.
- Bonuccelli A.
- Consolini R.
- Marseglia G. L.
- Peroni D.
- Striano P.
- Cordelli D.
- Savasta S.
DOIAbstract
Objectives: Sydenham's Chorea (SC) is a neuropsychiatric disorder and a major manifestation of acute rheumatic fever. The erroneous assumption that SC is a benign and self-limiting disease, has led to a lack of high-quality scientific evidence of the therapeutical and prognostic features of SC. Study design: We retrospectively analyzed the medical records of patients <18-years old with SC in 17 Italian pediatric centers. Recorded data included clinical, instrumental and laboratory parameters. Prognostic risk factors including treatment regimens were assessed with univariate and multivariate sub-analysis. Results: We included 171 patients with SC. 66% had generalized chorea, and 34% hemichorea. 81% had carditis (subclinical in 65%). Addition...
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