Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis
- Palma C.
- La Rocca C.
- Gigantino V.
- Aquino G.
- Piccaro G.
- Di Silvestre D.
- Brambilla F.
- Rossi R.
- Bonacina F.
- Lepore M. T.
- Audano M.
- Mitro N.
- Botti G.
- Bruzzaniti S.
- Fusco C.
- Procaccini C.
- De Rosa V.
- Galgani M.
- Alviggi C.
- Puca A.
- Grassi F.
- Rezzonico-Jost T.
- Norata G. D.
- Mauri P.
- Netea M. G.
- de Candia P.
- Matarese G.
Publication date
January 2021
DOIAbstract
Through an in vivo model of high susceptibility to MTB infection in DBA/2 mice, we utilized a multi-omic approach to show that caloric restriction (CR) is able to control pulmonary MTB infection and associated inflammatory damage through an immunometabolic reprogramming and enhanced anti-MTB capacity of immune cells. These data candidate CR as a novel strategy in the management of MTB infection in countries where TB is rapidly increasing in association with over-nutrition and obesity
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