Many recent research studies have focused on developing innovative seismic-resilient structural systems to reduce repair costs and downtime in the aftermath of an earthquake. In this regard, dealing with steel Moment Resisting Frames (MRFs), recent research works have demonstrated the benefit deriving from the adoption of both low-damage and self-centring column base connections, both in terms of damage and residual drifts reduction. Although several technologies have been developed in this direction, only a few research studies investigated the significant parameters influencing the self-centring capability of these systems. Within this framework, the present study investigates the influence of the frame layout (i.e., storeys and bays numb...