Add to ORKGNew indolo- and pyrrolo-pyrimidines of type 1-4 were studied for their ability to form stable complexes with DNA fragments. The calculated free energies of binding were found in the range -8.39 \uf7 -16.72 Kcal/mol. The docking studies revealed a common binding mode with the chromophore intercalated between GC base pairs whereas the side chain lies along the minor groove
Previously, we designed and synthesized the 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione...
Deoxyribonuclic acid (DNA) is the most relevant intracellular target for a wide variety of anticance...
The natural product distamycin contains three N-methylpyrrole amino acids and binds in the minor gro...
New classes of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors were studied in si...
Molecular docking is a computational technique utilized in the field of structural biology and drug ...
Pyrrolobenzodiazepines (PBDs) are naturally occurring antitumour antibiotics that interact and bind ...
The design of new series of pyrrolo-pyrimidine derivatives, further annelated with a third heterocyc...
Eight indole derivatives were studied for their DNA binding ability using fluorescence quenching an...
Molecular docking is a widely used computational technique used to find the probabilistic binding si...
G‐quadruplex (G4) DNA structures are linked to fundamental biological processes and human diseases, ...
Pyrrolobenzodiazepines (PBD) are a group of naturally occurring antitumor antibiotics that consist o...
Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groo...
This work was focused on understanding the interaction mechanism of pyrazino[1,2-a]indole derivative...
Background: Cell-permeable small molecules that target predetermined DNA sequences with high affinit...
The in silico COMPARE analysis was performed on 8-[3-(piperidino)propyl]-4,10-dimethyl-9-phenyl-6-(m...
Previously, we designed and synthesized the 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione...
Deoxyribonuclic acid (DNA) is the most relevant intracellular target for a wide variety of anticance...
The natural product distamycin contains three N-methylpyrrole amino acids and binds in the minor gro...
New classes of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors were studied in si...
Molecular docking is a computational technique utilized in the field of structural biology and drug ...
Pyrrolobenzodiazepines (PBDs) are naturally occurring antitumour antibiotics that interact and bind ...
The design of new series of pyrrolo-pyrimidine derivatives, further annelated with a third heterocyc...
Eight indole derivatives were studied for their DNA binding ability using fluorescence quenching an...
Molecular docking is a widely used computational technique used to find the probabilistic binding si...
G‐quadruplex (G4) DNA structures are linked to fundamental biological processes and human diseases, ...
Pyrrolobenzodiazepines (PBD) are a group of naturally occurring antitumor antibiotics that consist o...
Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groo...
This work was focused on understanding the interaction mechanism of pyrazino[1,2-a]indole derivative...
Background: Cell-permeable small molecules that target predetermined DNA sequences with high affinit...
The in silico COMPARE analysis was performed on 8-[3-(piperidino)propyl]-4,10-dimethyl-9-phenyl-6-(m...
Previously, we designed and synthesized the 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione...
Deoxyribonuclic acid (DNA) is the most relevant intracellular target for a wide variety of anticance...
The natural product distamycin contains three N-methylpyrrole amino acids and binds in the minor gro...