Neurological Pupil Index for the Early Prediction of Outcome in Severe Acute Brain Injury Patients

Romagnosi, Federico
Bernini, Adriano
Bongiovanni, Filippo
Iaquaniello, Carolina
Miroz, John Paul
Citerio, Giuseppe
Taccone, Fabio
Oddo, Mauro

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Publication date

May 2022

DOI

10.3390/brainsci12050609

Publisher

MDPI AG

Abstract

In this study, we examined the early value of automated quantitative pupillary examination, using the Neurological Pupil index (NPi), to predict the long-term outcome of acute brain injured (ABI) patients. We performed a single-centre retrospective study (October 2016–March 2019) in ABI patients who underwent NPi measurement during the first 3 days following brain insult. We examined the performance of NPi—alone or in combination with other baseline demographic (age) and radiologic (CT midline shift) predictors—to prognosticate unfavourable 6-month outcome (Glasgow Outcome Scale 1–3). A total of 145 severely brain-injured subjects (65 traumatic brain injury, TBI; 80 non-TBI) were studied. At each time point tested, NPi <3 was highly predict...