Killing of tumor cells by cytotoxic therapies, such as chemotherapy or gamma-irradiation, is predominantly mediated by the activation of apoptotic pathways. Refractoriness to anticancer therapy is often due to a failure in the apoptotic pathway. The mechanisms that control the balance between survival and cell death in cancer cells are still largely unknown. Tumor cells have been shown to evade death signals through an increase in the expression of antiapoptotic molecules or loss of proapoptotic factors. We aimed to study the involvement of PED, a molecule with a broad antiapoptotic action, in human breast cancer cell resistance to chemotherapeutic drugs-induced cell death. We show that human breast cancer cells express high levels of PED a...
Resistance to chemotherapy is a major cause of treatment failure in human cancer. Accumulating evide...
Resistance to chemotherapy is a major cause of treatment failure in human cancer. Accumulating evide...
Evading apoptosis is considered to be a hallmark of cancer, because mutations in apoptotic regulator...
Killing of tumor cells by cytotoxic therapies, such as chemotherapy or gamma-irradiation, is predomi...
Killing of tumor cells by cytotoxic therapies, such as chemotherapy or gamma-irradiation, is predomi...
The antiapoptotic protein PED/PEA-15 features an Akt phosphorylation motif upstream from Ser(116). I...
PED (phosphoprotein enriched in diabetes) is a death-effector domain (DED) family member with a broa...
Breast cancer ranks as the second most common cause of cancer death among women in the United States...
[[abstract]]Resistance to chemotherapy is a major cause of treatment failure in human cancer. Accumu...
Paclitaxel (taxol) is extensively used for chemotherapy of various cancers including ovarian cancer....
Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs and rad...
PED (phosphoprotein enriched in diabetes) is a 15 KDa protein involved in many cellular pathways and...
The serine / threonine kinases, Akt1/PKB, Akt2/PKB, and Akt3 /PKB, play a critical role in preventin...
Resistance to chemotherapy is a major cause of treatment failure in human cancer. Accumulating evide...
Resistance to chemotherapy is a major cause of treatment failure in human cancer. Accumulating evide...
Evading apoptosis is considered to be a hallmark of cancer, because mutations in apoptotic regulator...
Killing of tumor cells by cytotoxic therapies, such as chemotherapy or gamma-irradiation, is predomi...
Killing of tumor cells by cytotoxic therapies, such as chemotherapy or gamma-irradiation, is predomi...
The antiapoptotic protein PED/PEA-15 features an Akt phosphorylation motif upstream from Ser(116). I...
PED (phosphoprotein enriched in diabetes) is a death-effector domain (DED) family member with a broa...
Breast cancer ranks as the second most common cause of cancer death among women in the United States...
[[abstract]]Resistance to chemotherapy is a major cause of treatment failure in human cancer. Accumu...
Paclitaxel (taxol) is extensively used for chemotherapy of various cancers including ovarian cancer....
Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs and rad...
PED (phosphoprotein enriched in diabetes) is a 15 KDa protein involved in many cellular pathways and...
The serine / threonine kinases, Akt1/PKB, Akt2/PKB, and Akt3 /PKB, play a critical role in preventin...
Resistance to chemotherapy is a major cause of treatment failure in human cancer. Accumulating evide...
Resistance to chemotherapy is a major cause of treatment failure in human cancer. Accumulating evide...
Evading apoptosis is considered to be a hallmark of cancer, because mutations in apoptotic regulator...