The KLOE experiment has acquired an integrated luminosity greater than 2.5 fb^{-1} at the peak of ø-resonance on the e^{+]e^{-} DAΦNE collider in the Frascati National Laboratory (LNF). New data taking with the upgraded detector (KLOE-2) and DAΦNE should start in the end of 2011. Main modifications of the detector and new interaction region give a unique possibility to collect about 20 fb^{-1} in 3 years. The KLOE-2 wide scientific program which contains the experimental study of CP and CPT symmetries, quantum decoherence, γγ physics and search of the dark matter is presented and briefly discussed