[[alternative]]Nutritional Status of Patients with Lung Adenocarcinoma Associated with Systemic Chemotherapy Care of Research

[[abstract]]本研究探討肺腺癌患者行全身性化學治療期間的營養狀況與化學治療照護之間的相關性，將營養狀況視為癌症患者照顧的一環，檢視營養狀況在患者行化學治療時的相關性究竟為何，屬於相關性研究，並非介入性的研究設計。分析資料取自台中榮民總醫院「癌症個案管理資料庫」之西元2011年起至2014年為止之肺腺癌患者，本研究針對20歲以上、初次罹患肺腺癌、行全身性化學治療的81位研究對象進行相關性分析。 研究分析結果顯示，血紅素及身體質量指數在化學治療前後經由配對t相關性分析達統計上的顯著差異；經多元迴歸分析結果人口學變項及營養狀況與化學治療次數之間無顯著的相關性。使用Super Mix混合模型分析軟體的多層次模式（multi-level modeling, MLM）的Maximum likelihood estimate分析結果吸菸、身體質量指數以及血紅素等三個變項對絕對嗜中性白血球有顯著的影響；以羅吉斯迴歸進行分析噁心、嘔吐、食慾不振、口腔潰瘍與各變項結果，發現血紅素對噁心及食慾不振有負向且顯著的影響，又Odds ratio結果得知，每增加一個單位的血紅素，產生噁心的機率少0.677倍，產生食慾不振的機率少0.583倍。本研究結果雖然受限於二手資料，在少數研究樣本數中，可能造成統計上樣本數過少的偏誤，但是，另一方面使用較高的統計檢定力（power）軟體精確地探討分析研究結果。未來須以建構完整營養照護方案並落實團隊照護為方向，才能為患者謀福利；另外，將來研究方面則需要以更嚴謹的實驗設計，進行營養狀況與化學治療照護相關性分析。[[abstract]]This study investigated the correlation between the nutritional status of patients with lung adenocarcinoma during chemotherapy and systemic chemotherapy care, regarded as the nutritional status of cancer patients to take care of a ring, view the nutritional status of patients during chemotherapy correlated exactly why, belong to the relevant research is not involved in the study design in nature. Analysis of data from the Taichung Veterans General Hospital of lung cancer patients in 2011 AD until 2014's "cancer case management database," In this study, over 20 years old, suffering from lung adenocarcinoma for the first time, performed systemic chemotherapy correlation analysis 81 study subjects. Research analysis showed that hemoglobin and body mass index before and after chemotherapy via a paired t correlation analysis of significant discrepancies in the statistics. Use Super Mix mixed model analysis software of multi-level mode (MLM) Maximum likelihood estimate of the results of the analysis of smoking, body mass index and hemoglobin three variables have a significant impact on the absolute neutrophils, with logistic regression analyze nausea, vomiting, loss of appetite, mouth ulcers with variable results, found that hemoglobin nausea and loss of appetite have negative and significant impact, and that the results of Odds ratio, each additional unit of hemoglobin, nausea 0.677 times less chance of generating less chance of loss of appetite 0.583 times. Although the results of this study is limited to second-hand information, the number of samples in a few studies, it may result in statistics on the number of samples is too small bias, but on the other hand the use of higher statistical test force (power) analysis software to accurately investigate the findings . In the future we shall establish a comprehensive nutrition care plan and implement care for the direction of the team in order to benefit patients.In addition, the future research will need to be more rigorous experimental design, the nutritional status and chemotherapy care correlation analysis