[[alternative]]Consideration and Application of Placebo in Clinical Nursing Research

[[abstract]]近年來研究之安慰劑議題已逐漸受到重視。基礎科學家開始從神經生理及心理學的過程去解釋安慰劑反應的調節過程。安慰劑作用受疾病變異的影響，例如疾病自然過程，而病人或醫師的偏誤也會造成對安慰劑作用的錯誤解釋。爲了透過安慰劑控制組試驗移除安慰劑作用，安慰組合併雙盲隨機之實驗設計，儼然成爲現代臨床試驗之黃金準則。因此，本文將探討安慰劑、安慰劑作用、安慰劑機轉、倫理與方法學等議題，以作爲護理介入措施研究之設計參考。[[abstract]]In recent years, placebo becomes an important issue in evidence-based research. Basic sciences started elucidating the neurobiological and psychological processes that mediate the placebo response. A placebo effect is affected by the variation of illness, such as the natural course of disease. Patient or physician bias can also cause misinterpretation of the placebo effect. In research, the placebo effect is therapeutic noise to be removed by placebo-controlled trials. Thus, a randomized, double-blind, placebo-controlled trial has emerged as the gold standard in modern clinical study. The purpose of this article was to discuss the issue related to placebo, placebo effects, placebo mechanism, ethics of using placebos, and methodology referring to intervention research design of the clinical research in nursing