Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial

Arjyal, Amit
Basnyat, Buddha
Nhan, Ho Thi
Koirala, Samir
Giri, Abhishek
Joshi, Niva
Shakya, Mila
Pathak, Kamal Raj
Mahat, Saruna Pathak
Prajapati, Shanti Pradhan
Adhikari, Nabin
Thapa, Rajkumar
Merson, Laura
Gajurel, Damodar
Lamsal, Kamal
Lamsal, Dinesh
Yadav, Bharat Kumar
Shah, Ganesh
Shrestha, Poojan
Dongol, Sabina
Karkey, Abhilasha
Thompson, Corinne
Thieu, Nga Tran Vu
Thanh, Duy Pham
Baker, Stephen
Thwaites, Guy E
Wolbers, Marcel
Dolecek, Christiane

Open link

Publication date

January 2016

DOI

10.1016/S1473-3099(15)00530-7

Publisher

The Lancet Infectious Diseases

Abstract

Data supporting a publication on the potential benefits of using gatifloxacin to treat Enteric (typhoid) fever, in comparison to cephalosporin ceftriaxone

Extracted data

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Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial

Arjyal, Amit
Basnyat, Buddha
Nhan, Ho Thi
Koirala, Samir
Giri, Abhishek
Joshi, Niva
Shakya, Mila
Pathak, Kamal Raj
Mahat, Saruna Pathak
Prajapati, Shanti Pradhan
Adhikari, Nabin
Thapa, Rajkumar
Merson, Laura
Gajurel, Damodar
Lamsal, Kamal
Lamsal, Dinesh
Yadav, Bharat Kumar
Shah, Ganesh
Shrestha, Poojan
Dongol, Sabina
Karkey, Abhilasha
Thompson, Corinne
Thieu, Nga Tran Vu
Thanh, Duy Pham
Baker, Stephen
Thwaites, Guy E
Wolbers, Marcel
Dolecek, Christiane

Open link

Publication date

January 2016

DOI

10.1016/S1473-3099(15)00530-7

Publisher

The Lancet Infectious Diseases

Abstract

Data supporting a publication on the potential benefits of using gatifloxacin to treat Enteric (typhoid) fever, in comparison to cephalosporin ceftriaxone

Extracted data

Dolecek Christiane
Phi La Tran Thi
Rang Nguyen Ngoc
Phuong Le Thi
Vinh Ha
Tuan Phung Quoc
Cong Du Doan
Be Bay Nguyen Thi
Long Duong Thanh
Ha Luong Bich
Binh Nguyen Trung
Anh Hong Nguyen Thi
Dung Pham Ngoc
Lanh Mai Ngoc
Be Bay Phan Van
Ho Vo Anh
Van Minh Hoang Nguyen
Nga Tran Thu Thi
Chau Tran Thuy
Schultsz Constance
Dunstan Sarah J.
Stepniewska Kasia
Campbell James Ian
Song Diep To
Basnyat Buddha
Vinh Chau Nguyen Van
Van Sach Nguyen
Chinh Nguyen Tran
Hien Tran Tinh
Farrar Jeremy

May 2008

Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotic...

Treatment response in enteric fever in an era of increasing antimicrobial resistance: an individual patient data analysis of 2,092 participants enrolled into four randomised controlled trials in Nepal.

Thompsom, C.N.
Karkey, A.
Dongol, S.
Ariyal, A.
Wolbers, M.
Darton, T.
Farrar, J.J.
Thwaites, G.E.
Dolecek, C.
Basnyat, B.
Baker, S.

February 2017

Background: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cau...

Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial

Arjyal, Amit
Basnyat, Buddha
Nhan, Ho Thi
Koirala, Samir
Giri, Abhishek
Joshi, Niva
Shakya, Mila
Pathak, Kamal Raj
Mahat, Saruna Pathak
Prajapati, Shanti Pradhan
Adhikari, Nabin
Thapa, Rajkumar
Merson, Laura
Gajurel, Damodar
Lamsal, Kamal
Lamsal, Dinesh
Yadav, Bharat Kumar
Shah, Ganesh
Shrestha, Poojan
Dongol, Sabina
Karkey, Abhilasha
Thompson, Corinne
Thieu, Nga Tran Vu
Thanh, Duy Pham
Baker, Stephen
Thwaites, Guy E
Wolbers, Marcel
Dolecek, Christiane

January 2016

Data supporting a publication on the potential benefits of using gatifloxacin to treat Enteric (typh...

Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial.

Arjyal, A
Basnyat, B
Nhan, H
Koirala, S
Giri, A
Joshi, N
Shakya, M
Pathak, K
Mahat, S
Prajapati, S
Adhikari, N
Thapa, R
Merson, L
Gajurel, D
Lamsal, K
Lamsal, D
Yadav, B
Shah, G
Shrestha, P
Dongol, S
Karkey, A
Thompson, C
Thieu, N
Thanh, D
Baker, S
Thwaites, G
Wolbers, M
Dolecek, C

January 2016

Because treatment with third-generation cephalosporins is associated with slow clinical improvement ...

Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial

Arjyal, Amit
Basnyat, Buddha
Nhan, Ho Thi
Koirala, Samir
Giri, Abhishek
Joshi, Niva
Shakya, Mila
Pathak, Kamal Raj
Mahat, Saruna Pathak
Prajapati, Shanti Pradhan
Adhikari, Nabin
Thapa, Rajkumar
Merson, Laura
Gajurel, Damodar
Lamsal, Kamal
Lamsal, Dinesh
Yadav, Bharat Kumar
Shah, Ganesh
Shrestha, Poojan
Dongol, Sabina
Karkey, Abhilasha
Thompson, Corinne N
Thieu, Nga Tran Vu
Thanh, Duy Pham
Baker, Stephen
Thwaites, Guy E
Wolbers, Marcel
Dolecek, Christiane

May 2016

SummaryBackgroundBecause treatment with third-generation cephalosporins is associated with slow clin...

Gatifloxacin versus ofloxacin for the treatment of uncomplicated enteric fever in Nepal: an open-label, randomized, controlled trial

Koirala, S
Basnyat, B
Arjyal, A
Shilpakar, O
Shrestha, K
Shrestha, R
Shrestha, UM
Agrawal, K
Koirala, KD
Thapa, SD
Karkey, A
Dongol, S
Giri, A
Shakya, M
Pathak, KR
Campbell, J
Baker, S
Farrar, J
Wolbers, M
Dolecek, C

October 2013

BACKGROUND: Fluoroquinolones are the most commonly used group of antimicrobials for the treatment of...

Gatifloxacin Versus Ofloxacin for the Treatment of Uncomplicated Enteric Fever in Nepal: An Open-Label, Randomized, Controlled Trial

Samir Koirala
Buddha Basnyat
Amit Arjyal
Olita Shilpakar
Kabina Shrestha
Rishav Shrestha
Upendra Man Shrestha
Krishna Agrawal
Kanika Deshp
E Koirala
Sudeep Dhoj Thapa
Abhilasha Karkey
Sabina Dongol
Abhishek Giri
Mila Shakya
Kamal Raj Pathak
James Campbell
Stephen Baker
Jeremy Farrar
Marcel Wolbers
Christiane Dolecek

August 2016

Background: Fluoroquinolones are the most commonly used group of antimicrobials for the treatment of...

An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever.

Anil Pandit
Amit Arjyal
Jeremy N Day
Buddhi Paudyal
Sabina Dangol
Mark D Zimmerman
Bharat Yadav
Kasia Stepniewska
James I Campbell
Christiane Dolecek
Jeremy J Farrar
Buddha Basnyat

June 2007

To assess the efficacy of gatifloxacin versus cefixime in the treatment of uncomplicated culture pos...

Gatifloxacin versus chloramphenicol for uncomplicated enteric fever: an open-label, randomised, controlled trial

Arjyal, Amit
Basnyat, Buddha
Koirala, Samir
Karkey, Abhilasha
Dongol, Sabina
Agrawaal, Krishna Kumar
Shakya, Nikki
Shrestha, Kabina
Sharma, Manish
Lama, Sanju
Shrestha, Kasturi
Khatri, Nely Shrestha
Shrestha, Umesh
Campbell, James I
Baker, Stephen
Farrar, Jeremy
Wolbers, Marcel
Dolecek, Christiane

June 2011

SummaryBackgroundWe aimed to investigate whether gatifloxacin, a new generation and affordable fluor...

An Open Randomized Comparison of Gatifloxacin versus Cefixime for the Treatment of Uncomplicated Enteric Fever

Pandit Anil
Arjyal Amit
Day Jeremy N.
Paudyal Buddhi
Dangol Sabina
Zimmerman Mark D.
Yadav Bharat
Stepniewska Kasia
Campbell James I.
Dolecek Christiane
Farrar Jeremy J.
Basnyat Buddha

June 2007

To assess the efficacy of gatifloxacin versus cefixime in the treatment of uncomplicated culture pos...

Gatifloxacin versus chloramphenicol for uncomplicated enteric fever: an open-label, randomised, controlled trial.

Arjyal, A
Basnyat, B
Koirala, S
Karkey, A
Dongol, S
Agrawaal, KK
Shakya, N
Shrestha, K
Sharma, M
Lama, S
Shrestha, K
Khatri, NS
Shrestha, U
Campbell, JI
Baker, S
Farrar, J
Wolbers, M
Dolecek, C

June 2011

BACKGROUND: We aimed to investigate whether gatifloxacin, a new generation and affordable fluoroquin...

Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance: An Individual Patient Data Analysis of 2092 Participants Enrolled into 4 Randomized, Controlled Trials in Nepal.

Thompson, Corinne N
Karkey, Abhilasha
Dongol, Sabina
Arjyal, Amit
Wolbers, Marcel
Darton, Thomas
Farrar, Jeremy J
Thwaites, Guy E
Dolecek, Christiane
Basnyat, Buddha
Baker, Stephen

June 2017

Background.: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading ca...

Treatment response in enteric fever in an era of increasing antimicrobial resistance: an individual patient data analysis of 2092 participants enrolled into 4 randomized, controlled trials in Nepal

Thompson, CN
Karkey, A
Dongol, S
Ariyal, A
Wolbers, M
Darton, T
Farrar, JJ
Thwaites, G
Dolecek, C
Basnyat, B
Baker, S

February 2017

Background: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cau...

A multi-center randomised controlled trial of gatifloxacin versus azithromycin for the treatment of uncomplicated typhoid fever in children and adults in Vietnam.

Dolecek, C
Tran, T
Nguyen, N
Le, T
Ha, V
Phung, Q
Doan, C
Nguyen, T
Duong, T
Luong, B
Nguyen, T
Nguyen, T
Pham, N
Mai, N
Phan, V
Vo, A
Nguyen, V
Tran, T
Tran, T
Schultsz, C
Dunstan, S
Stepniewska, K
Campbell, J
To, S
Basnyat, B
Nguyen, V
Nguyen, V
Nguyen, T
Tran, T
Farrar, J

January 2008

BACKGROUND: Drug resistant typhoid fever is a major clinical problem globally. Many of the first lin...

A Multi-Center Randomised Controlled Trial of Gatifloxacin versus Azithromycin for the Treatment of Uncomplicated Typhoid Fever in Children and Adults in Vietnam

Dolecek Christiane
Phi La Tran Thi
Rang Nguyen Ngoc
Phuong Le Thi
Vinh Ha
Tuan Phung Quoc
Cong Du Doan
Be Bay Nguyen Thi
Long Duong Thanh
Ha Luong Bich
Binh Nguyen Trung
Anh Hong Nguyen Thi
Dung Pham Ngoc
Lanh Mai Ngoc
Be Bay Phan Van
Ho Vo Anh
Van Minh Hoang Nguyen
Nga Tran Thu Thi
Chau Tran Thuy
Schultsz Constance
Dunstan Sarah J.
Stepniewska Kasia
Campbell James Ian
Song Diep To
Basnyat Buddha
Vinh Chau Nguyen Van
Van Sach Nguyen
Chinh Nguyen Tran
Hien Tran Tinh
Farrar Jeremy

May 2008

Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotic...

Thompsom, C.N.
Karkey, A.
Dongol, S.
Ariyal, A.
Wolbers, M.
Darton, T.
Farrar, J.J.
Thwaites, G.E.
Dolecek, C.
Basnyat, B.
Baker, S.

February 2017

Background: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cau...

Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial

Arjyal, Amit
Basnyat, Buddha
Nhan, Ho Thi
Koirala, Samir
Giri, Abhishek
Joshi, Niva
Shakya, Mila
Pathak, Kamal Raj
Mahat, Saruna Pathak
Prajapati, Shanti Pradhan
Adhikari, Nabin
Thapa, Rajkumar
Merson, Laura
Gajurel, Damodar
Lamsal, Kamal
Lamsal, Dinesh
Yadav, Bharat Kumar
Shah, Ganesh
Shrestha, Poojan
Dongol, Sabina
Karkey, Abhilasha
Thompson, Corinne
Thieu, Nga Tran Vu
Thanh, Duy Pham
Baker, Stephen
Thwaites, Guy E
Wolbers, Marcel
Dolecek, Christiane

January 2016

Data supporting a publication on the potential benefits of using gatifloxacin to treat Enteric (typh...

Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial.

Arjyal, A
Basnyat, B
Nhan, H
Koirala, S
Giri, A
Joshi, N
Shakya, M
Pathak, K
Mahat, S
Prajapati, S
Adhikari, N
Thapa, R
Merson, L
Gajurel, D
Lamsal, K
Lamsal, D
Yadav, B
Shah, G
Shrestha, P
Dongol, S
Karkey, A
Thompson, C
Thieu, N
Thanh, D
Baker, S
Thwaites, G
Wolbers, M
Dolecek, C

January 2016

Because treatment with third-generation cephalosporins is associated with slow clinical improvement ...

Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial

Arjyal, Amit
Basnyat, Buddha
Nhan, Ho Thi
Koirala, Samir
Giri, Abhishek
Joshi, Niva
Shakya, Mila
Pathak, Kamal Raj
Mahat, Saruna Pathak
Prajapati, Shanti Pradhan
Adhikari, Nabin
Thapa, Rajkumar
Merson, Laura
Gajurel, Damodar
Lamsal, Kamal
Lamsal, Dinesh
Yadav, Bharat Kumar
Shah, Ganesh
Shrestha, Poojan
Dongol, Sabina
Karkey, Abhilasha
Thompson, Corinne N
Thieu, Nga Tran Vu
Thanh, Duy Pham
Baker, Stephen
Thwaites, Guy E
Wolbers, Marcel
Dolecek, Christiane

May 2016

SummaryBackgroundBecause treatment with third-generation cephalosporins is associated with slow clin...

Gatifloxacin versus ofloxacin for the treatment of uncomplicated enteric fever in Nepal: an open-label, randomized, controlled trial

Koirala, S
Basnyat, B
Arjyal, A
Shilpakar, O
Shrestha, K
Shrestha, R
Shrestha, UM
Agrawal, K
Koirala, KD
Thapa, SD
Karkey, A
Dongol, S
Giri, A
Shakya, M
Pathak, KR
Campbell, J
Baker, S
Farrar, J
Wolbers, M
Dolecek, C

October 2013

BACKGROUND: Fluoroquinolones are the most commonly used group of antimicrobials for the treatment of...

Gatifloxacin Versus Ofloxacin for the Treatment of Uncomplicated Enteric Fever in Nepal: An Open-Label, Randomized, Controlled Trial

Samir Koirala
Buddha Basnyat
Amit Arjyal
Olita Shilpakar
Kabina Shrestha
Rishav Shrestha
Upendra Man Shrestha
Krishna Agrawal
Kanika Deshp
E Koirala
Sudeep Dhoj Thapa
Abhilasha Karkey
Sabina Dongol
Abhishek Giri
Mila Shakya
Kamal Raj Pathak
James Campbell
Stephen Baker
Jeremy Farrar
Marcel Wolbers
Christiane Dolecek

August 2016

Background: Fluoroquinolones are the most commonly used group of antimicrobials for the treatment of...

An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever.

Anil Pandit
Amit Arjyal
Jeremy N Day
Buddhi Paudyal
Sabina Dangol
Mark D Zimmerman
Bharat Yadav
Kasia Stepniewska
James I Campbell
Christiane Dolecek
Jeremy J Farrar
Buddha Basnyat

June 2007

To assess the efficacy of gatifloxacin versus cefixime in the treatment of uncomplicated culture pos...

Gatifloxacin versus chloramphenicol for uncomplicated enteric fever: an open-label, randomised, controlled trial

Arjyal, Amit
Basnyat, Buddha
Koirala, Samir
Karkey, Abhilasha
Dongol, Sabina
Agrawaal, Krishna Kumar
Shakya, Nikki
Shrestha, Kabina
Sharma, Manish
Lama, Sanju
Shrestha, Kasturi
Khatri, Nely Shrestha
Shrestha, Umesh
Campbell, James I
Baker, Stephen
Farrar, Jeremy
Wolbers, Marcel
Dolecek, Christiane

June 2011

SummaryBackgroundWe aimed to investigate whether gatifloxacin, a new generation and affordable fluor...

An Open Randomized Comparison of Gatifloxacin versus Cefixime for the Treatment of Uncomplicated Enteric Fever

Pandit Anil
Arjyal Amit
Day Jeremy N.
Paudyal Buddhi
Dangol Sabina
Zimmerman Mark D.
Yadav Bharat
Stepniewska Kasia
Campbell James I.
Dolecek Christiane
Farrar Jeremy J.
Basnyat Buddha

June 2007

To assess the efficacy of gatifloxacin versus cefixime in the treatment of uncomplicated culture pos...

Gatifloxacin versus chloramphenicol for uncomplicated enteric fever: an open-label, randomised, controlled trial.

Arjyal, A
Basnyat, B
Koirala, S
Karkey, A
Dongol, S
Agrawaal, KK
Shakya, N
Shrestha, K
Sharma, M
Lama, S
Shrestha, K
Khatri, NS
Shrestha, U
Campbell, JI
Baker, S
Farrar, J
Wolbers, M
Dolecek, C

June 2011

BACKGROUND: We aimed to investigate whether gatifloxacin, a new generation and affordable fluoroquin...

Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance: An Individual Patient Data Analysis of 2092 Participants Enrolled into 4 Randomized, Controlled Trials in Nepal.

Thompson, Corinne N
Karkey, Abhilasha
Dongol, Sabina
Arjyal, Amit
Wolbers, Marcel
Darton, Thomas
Farrar, Jeremy J
Thwaites, Guy E
Dolecek, Christiane
Basnyat, Buddha
Baker, Stephen

June 2017

Background.: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading ca...

Treatment response in enteric fever in an era of increasing antimicrobial resistance: an individual patient data analysis of 2092 participants enrolled into 4 randomized, controlled trials in Nepal

Thompson, CN
Karkey, A
Dongol, S
Ariyal, A
Wolbers, M
Darton, T
Farrar, JJ
Thwaites, G
Dolecek, C
Basnyat, B
Baker, S

February 2017

Background: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cau...

A multi-center randomised controlled trial of gatifloxacin versus azithromycin for the treatment of uncomplicated typhoid fever in children and adults in Vietnam.

Dolecek, C
Tran, T
Nguyen, N
Le, T
Ha, V
Phung, Q
Doan, C
Nguyen, T
Duong, T
Luong, B
Nguyen, T
Nguyen, T
Pham, N
Mai, N
Phan, V
Vo, A
Nguyen, V
Tran, T
Tran, T
Schultsz, C
Dunstan, S
Stepniewska, K
Campbell, J
To, S
Basnyat, B
Nguyen, V
Nguyen, V
Nguyen, T
Tran, T
Farrar, J

January 2008

BACKGROUND: Drug resistant typhoid fever is a major clinical problem globally. Many of the first lin...

A Multi-Center Randomised Controlled Trial of Gatifloxacin versus Azithromycin for the Treatment of Uncomplicated Typhoid Fever in Children and Adults in Vietnam

Dolecek Christiane
Phi La Tran Thi
Rang Nguyen Ngoc
Phuong Le Thi
Vinh Ha
Tuan Phung Quoc
Cong Du Doan
Be Bay Nguyen Thi
Long Duong Thanh
Ha Luong Bich
Binh Nguyen Trung
Anh Hong Nguyen Thi
Dung Pham Ngoc
Lanh Mai Ngoc
Be Bay Phan Van
Ho Vo Anh
Van Minh Hoang Nguyen
Nga Tran Thu Thi
Chau Tran Thuy
Schultsz Constance
Dunstan Sarah J.
Stepniewska Kasia
Campbell James Ian
Song Diep To
Basnyat Buddha
Vinh Chau Nguyen Van
Van Sach Nguyen
Chinh Nguyen Tran
Hien Tran Tinh
Farrar Jeremy

May 2008

Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotic...

Thompsom, C.N.
Karkey, A.
Dongol, S.
Ariyal, A.
Wolbers, M.
Darton, T.
Farrar, J.J.
Thwaites, G.E.
Dolecek, C.
Basnyat, B.
Baker, S.

February 2017

Background: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cau...

Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial

Abstract

Extracted data

Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial

Abstract

Extracted data

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